Alpha-1 Antitrypsin Bvunzo

Zvemukati

• Chii chinonzi alpha-1 antitrypsin (AAT) bvunzo?
• Chii chinoshandiswa?
• Nei ini ndichida iyo AAT bvunzo?
• Chii chinoitika panguva yeAAT bvunzo?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve AAT bvunzo?
• Zvinyorwa

Chii chinonzi alpha-1 antitrypsin (AAT) bvunzo?

Uyu muyedzo unoyera huwandu hwealpha-1 antitrypsin (AAT) muropa. AAT ipuroteni inogadzirwa muchiropa. Inobatsira kuchengetedza mapapu ako kubva mukukuvara nezvirwere, senge emphysema uye chisingaperi obstructive pulmonary chirwere (COPD).

AAT inogadzirwa nemamwe majeni mumuviri wako. Majini ndiwo akakosha mayuniti enhaka akapfuudzwa kubva kuvabereki vako. Ivo vanotakura ruzivo rwunotarisa hunhu hwako hwakasarudzika, senge kukwirira uye ruvara rwemaziso. Wese munhu anowana nhaka maviri makopi ejeni anogadzira AAT, imwe kubva kuna baba vavo uye imwe kubva kuna amai vavo. Kana paine shanduko (shanduko) mune imwe kana ese ari maviri makopi ejeni iri, muviri wako unoita mashoma AAT kana AAT isingashande sezvainofanirwa kuita.

• Kana iwe uine maviri akachinja makopi ejeni, zvinoreva kuti une mamiriro anonzi kushomeka kweAAT. Vanhu vane chirwere ichi vane njodzi yakakwira yekuwana chirwere chemapapu kana kukuvara kwechiropa vasati vava nemakore makumi mana nemashanu.
• Kana iwe uine imwe yakachinja AAT geni, iwe unogona kunge uine zvakaderera pane zvakajairwa zviyero zveAAT, asi zvinyoro kana kusavapo zviratidzo zvechirwere. Vanhu vane rimwe mutated gene ndivo vanotakura kushomeka kweAAT. Izvi zvinoreva kuti hauna chimiro, asi iwe unogona kupfuudza iyo geni rakachinjika kune vana vako.

Chiyero cheAAT chinogona kubatsira kuratidza kana iwe uine magene ekuchinja ayo anokuisa iwe panjodzi yechirwere.

Mamwe mazita: A1AT, AAT, alpha-1-antiprotease kushomeka, α1-antitrypsin

Chii chinoshandiswa?

Chiyero cheAAT chinowanzo shandiswa kubatsira kuongorora kushomeka kweAAT muvanhu vanoita chirwere chemapapu vachiri vadiki (makore makumi mana nemashanu kana mudiki) uye vasina zvimwe zvinenjodzi sekusvuta.

Iyo bvunzo inogona zvakare kushandiswa kuongorora isingawanzo fomu yechiropa chirwere mune vacheche.

Nei ini ndichida iyo AAT bvunzo?

Iwe ungangoda bvunzo yeAAT kana iwe uri pasi pemakore makumi mana nemashanu, usiri kusvuta, uye uine zviratidzo zvehosha yemapapu, kusanganisira:

• Kushungurudza
• Kufema kwekufema
• Chisingaperi chikosoro
• Inokurumidza kupfuura kurova kwemoyo paunosimuka
• Matambudziko ekuona
• Chirwere chisingapindure zvakanaka pakurapa

Iwe unogona zvakare kuwana uyu muedzo kana iwe uine nhoroondo yemhuri yekushomeka kweAAT.

Kushomeka kweAAT muvana kazhinji kunokanganisa chiropa. Saka mwana wako angangoda bvunzo yeAAT kana iye mupi wezvehutano akawana zviratidzo zvechiropa chirwere. Izvi zvinosanganisira:

• Jaundice, yero yeganda uye maziso anogara kweinopfuura vhiki kana maviri
• Yakawedzera spleen
• Kakawanda kuchenesa

Chii chinoitika panguva yeAAT bvunzo?

Nyanzvi yezvehutano inotora muyero weropa kubva mutsinga iri muruoko rwako, uchishandisa tsono diki. Mushure mekunge tsono yaiswa, kashoma reropa kanounganidzwa muthubhu yekuyedza kana muhombodo. Unogona kunzwa kakuruma kana tsono ichipinda kana kubuda. Izvi zvinowanzotora maminetsi asingasviki mashanu.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe haudi chero yakakosha gadziriro yeAAT bvunzo.

Pane here njodzi kune bvunzo?

Pane panjodzi diki yemuviri pakuongororwa kweropa. Unogona kunge uine marwadzo mashoma kana kupwanya panzvimbo yakaiswa tsono, asi zviratidzo zvizhinji zvinokurumidza kupera.

Zvinorevei mhedzisiro yacho?

Kana mhedzisiro yako ikaratidza yakaderera pane yakajairwa huwandu hweAAT, zvingangoreva kuti une imwe kana maviri akachinjika maAAT majini. Iyo yakadzika iyo nhanho, zvakanyanya mukana iwe uine maviri akachinja majini uye kushomeka kweAAT.

Kana iwe ukaonekwa uine kushomeka kweAAT, iwe unogona kutora matanho ekudzora njodzi yako yechirwere. Izvi zvinosanganisira:

• Kwete kusvuta. Kana iwe uri fodya, rega kuputa. Ukasasvuta, usatange. Kusvuta ndiko kunokonzeresa njodzi yehupenyu hunotyisidzira chirwere chemapapu muvanhu vane kushomeka kweAAT.
• Kutevera kudya kunovaka muviri
• Kuwana kurovedza muviri nguva dzose
• Kuona wako mupi wezvehutano nguva dzose
• Kutora mishonga sezvakarairwa nemupi wako

Kana iwe uine mibvunzo nezve mhedzisiro yako, taura nemupi wako wezvehutano.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve AAT bvunzo?

Usati wabvuma kuyedzwa, zvinogona kubatsira kutaura nemudzidzisi wezvechibereko. A genetic chipangamazano inyanzvi yakadzidziswa mu genetics uye kuongororwa kwemajini. Mupi wezano anogona kukubatsira kuti unzwisise njodzi uye bhenefiti yekuyedzwa. Kana iwe ukaedzwa, chipangamazano anogona kukubatsira kuti unzwisise mhedzisiro uye nekupa ruzivo nezve mamiriro acho, kusanganisira njodzi yako yekuendesa chirwere ichi kuvana vako.

Zvinyorwa

1. Lab Kuedza Pamhepo [Internet]. Washington DC: American Association yeKiriniki Chemistry; c2001–2019. Arufa-1 Antitrypsin; [yakagadziridzwa 2019 Jun 7; yakataurwa 2019 Oct 1]; [angangoita maviri skrini. Inowanikwa kubva: https://labtestsonline.org/tests/alpha-1-antitrypsin
2. Lab Kuedza Pamhepo [Internet]. Washington DC: American Association yeKiriniki Chemistry; c2001–2019. Jaundice; [yakagadziridzwa 2018 Feb 2; yakataurwa 2019 Oct 1]; [angangoita matatu skrini. Inowanikwa kubva ku: https://labtestsonline.org/conditions/jaundice
3. Merck Chinyorwa Chevatengi Vhezheni [Internet]. Kenilworth (NJ): Merck & Co Inc. .; c2019. Alpha-1 Antitrypsin Kushomeka; [yakagadziridzwa 2018 Nov; yakataurwa 2019 Oct 1]; [angangoita maviri skrini. Inowanikwa kubva: https://www.merckmanuals.com/home/lung-and-airway-disorders/chronic-obstruction-pulmonary-disease-copd/alpha-1-antitrypsin-deficiency?query=alpha-1%20antitrypsin
4. National Mwoyo, Mapapu, uye Ropa Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Alpha-1 Antitrypsin Kushomeka; [yakataurwa 2019 Oct 1]; [angangoita maviri skrini. Inowanikwa kubva: https://www.nhlbi.nih.gov/health-topics/alpha-1-antitrypsin-deficiency
5. National Mwoyo, Mapapu, uye Ropa Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Kuedzwa kweropa; [yakataurwa 2019 Oct 1]; [angangoita matatu skrini. Inowanikwa kubva: https://www.nhlbi.nih.gov/health-topics/blood-tests
6. NIH U.S. National Raibhurari yeMishonga: Genetics Kumba Referensi [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Chii chinonzi gene? 2019 Oct 1 [yataurwa 2019 Oct 1]; [angangoita matatu skrini. Inowanikwa kubva: https://ghr.nlm.nih.gov/primer/basics/gene
7. UF Hutano: Yunivhesiti yeFlorida Hutano [Internet]. Gainesville (FL): Yunivhesiti yeFlorida Hutano; c2019. Alpha-1 antitrypsin ropa bvunzo: Ongororo; [yakagadziridzwa 2019 Oct 1; yakataurwa 2019 Oct 1]; [angangoita maviri skrini. Inowanikwa kubva: https://ufhealth.org/alpha-1-antitrypsin-blood-test
8. Yunivhesiti yeRochester Medical Center [Internet]. Rochester (NY): Yunivhesiti yeRochester Medical Center; c2019. Hutano Encyclopedia: Alpha-1 Antitrypsin; [yakataurwa 2019 Oct 1]; [angangoita maviri skrini. Inowanikwa kubva: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=alpha_1_antitrypsin
9. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2019. Alpha-1 Antitrypsin Genetic Testing: Chii chinonzi Alpha-1 Antitrypsin Kushomeka ?; [yakagadziridzwa 2018 Sep 5; yakataurwa 2019 Oct 1]; [angangoita maviri skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html
10. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2019. Alpha-1 Antitrypsin Genetic Testing: Chii chinonzi Genetic Counselling ?; [yakagadziridzwa 2018 Sep 5; yakataurwa 2019 Oct 1]; [angangoita 7 skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html#tv8548
11. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2019. Alpha-1 Antitrypsin Genetic Testing: Sei Ndisingazoyedzwa ?; [yakagadziridzwa 2018 Sep 5; yakataurwa 2019 Oct 1]; [angangoita 6 skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html#uf6790

Ruzivo ruri pane ino saiti harufanire kushandiswa sekutsiva kwehunyanzvi kurapwa kana kurairwa. Bata mupi wehutano kana iwe uine mibvunzo nezve hutano hwako.