Migraine Inogona Kuva Mune Mageneti Ako?

Zvemukati

• Migraine inogona kuva genetic here?
• Ko kutsvagurudza kunotii?
• Gene shanduko dzakabatana ne migraine
• Gene misiyano inosangana ne migraine
• Kune mamwe marudzi emigraine ane simba rakasimba rekuberekwa kupfuura mamwe?
• Kuva negene yekubatanidza kune migraine kunogona kukubatsira sei?
• Nguva yekuona chiremba
• Ndedzipi nzira dzakajairika dzekurapa?
• Mishonga yezvakanyanya migraine zviratidzo
• Mishonga inodzivirira migraine kurwisa
• Kubatanidza kurapa
• Chinokosha

Migraine chirwere chetsinga chinokanganisa vanhu vangangosvika mamirioni makumi mana muUnited States.

Migraine kurwisa kunowanzoitika kune rumwe rutivi rwemusoro. Dzimwe nguva dzinogona kutungamirwa kana kuperekedzwa nekukanganiswa kunoonekwa kana kwekunzwa kunozivikanwa seaura.

Zvimwe zviratidzo, senge kusvotwa, kurutsa, uye kupepuka kwekunzwa, zvinogona zvakare kuve zviripo panguva yekurwiswa kwemigraine.

Kunyange hazvo chikonzero chaicho chemigraine chisingazivikanwe, zvinofungidzirwa kuti zvese zviri zviviri zvakatipoteredza uye zvechibereko zvinoita chinzvimbo mumamiriro ezvinhu. Pazasi, isu tonyatso tarisa kubatana pakati pemigraine uye genetics.

Migraine inogona kuva genetic here?

DNA yako, ine majini ako, yakaiswa mumapara makumi maviri nematatu emakromosomes. Iwe unotora nhaka imwe seti yekromosomes kubva kuna amai vako uye imwe kubva kuna baba vako.

Jini chikamu cheDNA chinopa ruzivo rwekuti ungaita sei mapuroteni akasiyana mumuviri wako.

Dzimwe nguva majini anogona kuchinja, uye shanduko idzi dzinogona kukonzera kana kuisa munhu pane imwe hutano mamiriro. Aya majini shanduko anogona kutapudzwa kubva kumubereki kuenda kumwana.

Genetic changes kana misiyano yakabatanidzwa kune migraine. Muchokwadi, zvinofungidzirwa kuti inopfuura hafu yevanhu vane migraine vane imwe nhengo yemhuri inewo mamiriro acho.

Ko kutsvagurudza kunotii?

Ngatitorei kudzika kwakadzika mune izvo vatsvagiri vari kudzidza nezve genetics uye migraine.

Gene shanduko dzakabatana ne migraine

Iwe unogona kunge wakanzwa nezve kumwe kutsvagisa munhau maererano nezve akasiyana magene ekushandurwa achibatanidzwa ne migraine. Mimwe mienzaniso inosanganisira:

• KCNK18. Iyi geni inovhara puroteni inonzi TRESK, inosanganisirwa nemarwadzo ekurwadziwa uye inowanikwa munzvimbo dzemitsipa dzakakodzera migraine. Shanduko chaiyo mu KCNK18 kwave kuchizobatanidzwa ne migraine ne aura.
• CKIdelta. Iri geni rinovhara enzyme ine mabasa mazhinji mukati memuviri, imwe yacho inosangana neyako yekurara-wake kutenderera. Zvinoenderana neongororo ya2013, kwakasarudzika shanduko mu CKIdelta vaibatanidzwa ne migraine.

Gene misiyano inosangana ne migraine

Izvo zvakakosha kuratidza kuti kwakawanda migraine kurwisa kunofungidzirwa kuve polygenic. Izvi zvinoreva kuti majini mazhinji anobatsira kumamiriro acho. Izvi zvinoita kunge zvichikonzerwa nediki misiyano yemajini inonzi single-nucleotide polymorphisms (SNPs).

Zvidzidzo zveGenetic zvakaratidza zvinopfuura makumi mana nzvimbo dzemajini nemisiyano inosanganisirwa nemafomu akajairika emigraine. Idzi nzvimbo dzinowanzo kuve dzakabatana nezvinhu zvakaita semaseru uye neropa kusaina kana yevascular (yeropa mudziyo) basa.

Ndega, idzi misiyano inogona kuve nemhedzisiro. Nekudaro, kana mazhinji acho achiunganidza, zvinogona kubatsira mukukura kwemigraine.

Chidzidzo che2018 chemhuri 1,589 ine migraine chakawana "mutoro" wakawedzera weiyi misiyano yemagene ichienzaniswa nehuwandu hwevanhu.

Zvimwe zvakasiyana-siyana zvemajini zvinoratidzikawo kugadzirisa zvakasarudzika migraine maficha. Kuve neakasimba nhoroondo yemhuri yemigraine inogona kuwedzera njodzi yako yekuve ne:

• migraine ine aura
• inowanzoitika migraine kurwisa
• makore ekutanga emigraine kutanga
• mamwe mazuva apo iwe unofanirwa kushandisa mishonga yemigraine

Kune mamwe marudzi emigraine ane simba rakasimba rekuberekwa kupfuura mamwe?

Mamwe marudzi emigraine ane anozivikanwa mazita ekuberekwa. Muenzaniso weiyi ndeyemhuri hemiplegic migraine (FHM). Nekuda kwesangano rinozivikanwa, FHM yakave yakadzidzwa zvakanyanya zvine hukama neiyo genetics yemigraine.

FHM rudzi rwemigraine ine aura iyo inowanzo kuve nezera rekutanga rekutanga kupfuura mamwe marudzi emigraine. Pamwe pamwe nezvimwe zviratidzo zvinowanzoitika zveaura, vanhu vane FHM zvakare vane chiveve kana kushaya simba kune rimwe divi remuviri.

Kune matatu majini akasiyana anozivikanwa kuti anofambidzana neFHM. Vari:

• CACNA1A
• ATP1A2
• SCN1A

Shanduko mune imwe yemageneti aya inogona kukanganisa kusaina maseru, izvo zvinogona kukonzera kurwisa kwemigraine.

FHM inogarwa nenzira yakasarudzika ye autosomal. Izvi zvinoreva kuti iwe unongoda chete kopi imwe yeiyo mutated gene kuti uve nemamiriro acho.

Kuva negene yekubatanidza kune migraine kunogona kukubatsira sei?

Zvinogona kunge zvinonzwika sezvisingabvumirane, asi kuve nehunhu hwakabatana nemigraine kunogona kubatsira. Izvi zvinodaro nekuti iwe unogona kugamuchira ruzivo rwakakosha uye rutsigiro kubva kunhengo dzemhuri yako dzinonzwisisa mamiriro acho.

Ruzivo kubva kunhengo dzemhuri yako iyo inogona kubatsira kune yako wega migraine ruzivo inosanganisira:

• izvo zvinokonzera migraine
• iwo chaiwo maratidziro avanosangana nawo
• kurapwa kana mishonga inobatsira kunyatsogadzirisa zviratidzo zvavo zvemigraine
• kunyangwe kwavo kurwiswa kwemigraine kuchinja muhuwandu, kusimba, kana neimwe nzira muhupenyu hwavo hwese
• zera ravakatanga kusangana naro nemagraine

Nguva yekuona chiremba

Kana iwe uine zviratidzo zvinoenderana nemigraine, ita musangano nachiremba wako. Migraine kurwisa zviratidzo zvinosanganisira:

• kupuruzira kana kurwadziwa, kazhinji kune rumwe rutivi rwemusoro wako
• kusvotwa uye kurutsa
• chiedza chekunzwa
• kunzwisisika kwezwi
• aura zviratidzo, izvo zvinogona kutangira kurwisa kwemigraine uye zvinogona kusanganisira:
  • achiona kupenya kwechiedza
  • kuoma kutaura
  • manzwiro eutera kana chiveve kune rimwe divi rechiso chako kana mitezo

Dzimwe nguva kurwadziwa kwemusoro kunogona kuva chiratidzo chekukurumidzira kwekurapa. Wana kurapwa nekukurumidza kwemusoro uyo:

• inouya kamwe kamwe uye yakaoma
• zvinoitika zvichitevera kukuvara musoro wako
• inoitika nezviratidzo zvakaita sekuomesa mutsipa, kuvhiringidzika, kana kuti chiveve
• inogara kwenguva refu uye inowedzera kuwedzera mushure mekuzvishandisa nesimba

Ndedzipi nzira dzakajairika dzekurapa?

Migraine inowanzo kurapwa nemishonga. Kune maviri marudzi emigraine mishonga:

• izvo zvinorerutsa zvakanyanya migraine zviratidzo
• izvo zvinobatsira kudzivirira kurwisa kwemigraine kubva pakuitika

Kune zvekare dzimwe nzira dzekubatanidza dzinogona kushanda. Tichaongorora yega yega mhando yekurapa mune zvakadzama pazasi.

Mishonga yezvakanyanya migraine zviratidzo

Iwe unowanzo tora iyi mishonga nekukurumidza paunotanga kunzwa zviratidzo zveaura kana migraine kurwisa. Mienzaniso inosanganisira:

• Over-the-counter marwadzo mishonga. Izvi zvinosanganisira maNSAID senge ibuprofen (Advil, Motrin), naproxen (Aleve), uye aspirin. Acetaminophen (Tylenol) inogona zvakare kushandiswa.
• Triptans. Kune mhando zhinji dzetriptan. Iyi mishonga inobatsira kuvhara kuzvimba uye kudzikamisa tsinga dzeropa, kubvisa marwadzo. Mimwe mienzaniso inosanganisira sumatriptan (Imitrex), eletriptan (Relpax), uye rizatriptan (Maxalt).
• Ergot alkaloids. Iyi mishonga inoshanda nenzira yakafanana kune triptans. Vanogona kupihwa kana kurapwa netriptans kusingashandi. Mumwe muenzaniso ndeye dihydroergotamine (Migranal).
• Gepants. Iyi nyowani mutsva wemigraine mishonga inovhara peptide inopindirana nekuzvimba.
• Ditans. Mhuri inoverengeka yemishonga yekununura, madhimoni akafanana netriptan asi inogona kushandiswa kune vanhu vane nhoroondo yekurwadziwa kwemoyo uye sitiroko, sezvo triptan inogona kuwedzera njodzi yezvinetso zvemwoyo.

Mishonga inodzivirira migraine kurwisa

Chiremba wako anogona kunyorera mumwe wemishonga iyi kana uchigara uchirwiswa nemagraine zvakanyanya. Mimwe mienzaniso ndeiyi:

• Anticonvulsants. Iyi mishonga yakatanga kugadzirirwa kubatsira kubata kubata. Mienzaniso inosanganisira topiramate (Topamax) uye valproate.
• Ropa rekumanikidza mishonga. Izvi zvinogona kusanganisira beta-blockers kana calcium chiteshi blockers.
• Anodzvinyirira mishonga. Amitriptyline, tricyclic antidepressant, inogona kushandiswa.
• CGRP inhibitors. Iyi ndiyo mhando nyowani yemishonga inopihwa jekiseni. Iwo antibodies anosunga kune inogamuchira muuropi iyo inosimudzira vasodilation (kuwedzerwa kwemidziyo yeropa).
• Botox majekiseni. Kugamuchira jekiseni reBotox mavhiki gumi nemaviri ese kunogona kubatsira kudzivirira kurwisa kwemigraine kune vamwe vanhu vakuru.

Kubatanidza kurapa

Kune zvakare akasiyana marongero ekubatanidza anogona kuve anoshanda kune migraine, akadai se:

• Maitiro ekuzorora. Kushungurudzika kunowanzoitika migraine trigger. Maitiro ekuzorora anogona kukubatsira kuti usanyanya kunetseka. Mienzaniso inosanganisira iyo yoga, kufungisisa, kufema kurovedza muviri, uye kutandara kwemhasuru.
• Kugadzirira. Kugadziriswa kunosanganisira kuisa tsono dzakatetepa munzvimbo dzekumanikidza paganda. Izvi zvinofungidzirwa kubatsira kudzoreredza kuyerera kwesimba mumuviri. Zvinogona kubatsira kubvisa marwadzo emigraine.
• Miriwo, mavitamini, uye zvicherwa. Mimwe miriwo uye zvinowedzera zvinogona kubatsira nezviratidzo zvemigraine. Mienzaniso mishoma inosanganisira butterbur, magnesium, uye vhitamini B-2.

Chinokosha

Kunyange zvazvo vatsvakurudzi vakaona zvinogona kukonzera migraine, kuchine zvakawanda zvisingazivikanwe.

Nekudaro, kubva kutsvagurudzo yakaitwa, zvinoita sekusanganiswa kwakaomarara kwezvakatipoteredza uye nemagene zvinokonzeresa mamiriro aya.

Kuchinja kwemajini mune mamwe majekiseni kunoenderana nemamwe marudzi emigraine, senge mune zvemhuri hemiplegic migraine. Nekudaro, mazhinji marudzi emigraine anogona kunge ari polygenic, zvichireva kusiyanisa kwemageneti akati wandei kuchikonzera.

Kuva nenhoroondo yemhuri yemigraine kunogona kubatsira pakuti iwe unogona kuwana ruzivo rwakakosha kubva kunhengo dzemhuri dzinoona mamiriro akafanana. Iwe unogona kutopindura kurapwa kwakafanana.

Kana iwe uine migraine zviratidzo zvinoita kuti zvive zvakaoma kupfuurira kuburikidza nezuva, ona chiremba wako kuti akurukure zvaunogona kurapwa.