Ndeapi masero e dendritic ari uye zvaari

Zvemukati

• Ndezvipi zvakakosha
• Mhando dzedendritic maseru
• Maitiro avanogona kubatsira kurapa gomarara

Dendritic maseru, kana DC, ndiwo maseru anogadzirwa mumongo wemapfupa anogona kuwanikwa muropa, ganda uye kugaya uye kufema maturakiti, semuenzaniso, uye ayo ari chikamu chemuviri, ave nebasa rekuziva hutachiona nekuvandudza immune mhinduro.

Nekudaro, kana immune system ichinzwa kutyisidzirwa, maseru aya anoshanda kuitira kuti aone chinomiririra uye nekusimudzira kupera kwayo. Nekudaro, kana iyo dendritic masero ikasashanda mushe, immune system ine dambudziko rakawanda mukudzivirira muviri, nemukana wakakura wekuvandudza chirwere kana kunyangwe cancer.

Ndezvipi zvakakosha

Masero eDendritic ane basa rekutora iyo inopinda microorganism uye kuratidza maantigen, ayo anowanikwa pamusoro payo, kune maT lymphocyte, anotangisa immune immune kurwisa chirwere chinotapukira, kurwisa chirwere.

Nekuda kwekuti vanobata nekuburitsa maantigen pamusoro padzo, zvinova zvikamu zvehutachiona hunomiririra, masero e dendritic anonzi maAntigen-Anopa Masero, kana maAPC.

Kunze kwekusimudzira yekutanga immune mhinduro kurwisa imwe inopinda mumiririri uye ichivimbisa hutachiona hwekuzvarwa, masero e dendritic akakosha mukuvandudza kwekudzivirira hutachiona, inova ndiyo inogadzirwa maseru endangariro, ichidzivirira kuti irege kuitika zvakare kana nenzira yakapfava hutachiona nemuviri mumwe chete.

Nzwisisa mashandiro anoita immune system.

Mhando dzedendritic maseru

Dendritic maseru anogona kuverengerwa zvichienderana nehunhu hwavo hwekufamba, kuratidzwa kweanomaka pane yavo nzvimbo, nzvimbo uye basa. Nekudaro, dendritic maseru anogona kuverengerwa kunyanya mumhando mbiri:

• Plasmocytoid dendritic masero, ayo anowanikwa zvakanyanya muropa uye nhengo dze lymphoid, senge spleen, thymus, bone marora uye lymph node, semuenzaniso. Aya maseru anoshanda zvakanyanya kurwisa hutachiona uye, nekuda kwekugona kwavo kuburitsa Interferon alpha uye beta, ayo mapuroteni anoona nezve kudzora immune system, zvakare ane anti-bundu zvivakwa mune zvimwe zviitiko, kuwedzera kune antiviral kugona.
• Myeloid dendritic masero, ayo ari paganda, ropa uye mucosa. Iwo maseru ari muropa anonzi ekuvhiringidza DC, ayo anogadzira TNF-alpha, inova mhando yecytokine inokonzera kufa kwemamota maseru uye yekuzvimba maitiro. Mune tishu, aya maseru anogona kunzi kupindirana kana mucosal DC uye, kana aripo paganda, anonzi maLangerhans maseru kana maseru anotama, kubvira mushure mekumisikidza kwavo, vanofamba kuburikidza neganda kuenda kune lymph node, uko kwavanopa maantigen. kuna T lymphocytes.

Kwakatangira masero e dendritic ichiri kuongororwa zvakanyanya, asi zvinofungidzirwa kuti zvinogona kunge zvakabva kune ese lymphoid uye myeloid dzinza. Pamusoro pezvo, pane dzidziso mbiri dzinoedza kutsanangura mabviro emaseru aya:

1. Inoshanda Plasticity Model, uyo anofunga kuti mhando dzakasiyana dzedendritic maseru dzinomiririra nhanho dzakasiyana dzekukwirisa kweimwe sero mutsara, akasiyana mabasa ari mhedzisiro yenzvimbo yavari;
2. Yakasarudzika Lineage Model, uyo anofunga kuti mhando dzakasiyana dzedendritic maseru dzinotorwa kubva kwakasiyana maseru mitsara, chinova chikonzero chemabasa akasiyana.

Zvinotendwa kuti dzidziso dzese dzine hwaro uye kuti mumuviri zvingangoitika kuti dzidziso mbiri idzi dzinoitika panguva imwe chete.

Maitiro avanogona kubatsira kurapa gomarara

Nekuda kwebasa rayo rakakosha mumasikirwo ezvirwere mumuviri uye kugona kudzora mashandiro ese ane chekuita nekuzvidzivirira, zvidzidzo zvakaitwa nechinangwa chekuona kushanda kwayo pakurapa chirwere checancer, kunyanya muchimiro chemushonga.

Mu laboratori, masero e dendritic anoiswa mukubata nechuma maseru maseru uye kugona kwavo kubvisa maseru ekenza kunooneswa. Kana zvikaonekwa kuti mhedzisiro yemiyedzo yemhando dzekuyedza uye mhuka dzinoshanda, zvinokwanisika kuti bvunzo dzekenza yemukenza ine dendritic maseru inogona kupihwa kune vanhu. Kunyangwe ichive chivimbiso, zvimwe zvidzidzo zvinodiwa pakugadzirwa kwemushonga uyu, pamwe nerudzi rwegomarara urwo mushonga unokwanisa kurwisa.

Kunze kwekukwanisa kushandiswa pakurwisa gomarara, kuiswa kwema dendritic maseru kwakadzidzwawo pakurapa kurwisa AIDS uye systemic sporotrichosis, izvo zviri zvirwere zvakakomba uye zvinotungamira kudzikira kwema immune system. Hedzino dzimwe nzira dzekuvandudza nekusimbisa immune immune yako.