Clopidogrel, Oral Hwendefa

Zvemukati

• Pfungwa dzeclopidogrel
• Chii chinonzi clopidogrel?
• Nei zvichishandiswa
• Inoshanda sei
• Clopidogrel mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Clopidogrel inogona kusangana nemimwe mishonga
• Chirwere cheshuga
• Dumbu acid mishonga (proton pump inhibitors)
• Nonsteroidal anti-anogumbura zvinodhaka (NSAIDs)
• Ropa rakapfava
• Zvinodhaka zvinoshandiswa kurapa kushushikana
• Salicylates (asipurini)
• Opioid
• Maitiro ekutora clopidogrel
• Mafomu uye simba
• Chipimo chemushonga weacute coronary syndrome
• Chipimo chemushonga wemwoyo uchangoburwa, sitiroko ichangoburwa, kana chirwere chepfungwa chekuparara
• Clopidogrel yambiro
• FDA Yambiro: Chiropa basa yambiro
  
• Nyevero yakakomba yekubuda ropa
• Yambiro yekuvhiyiwa kana maitiro
• Allergy yambiro
• Kudhakwa kudyidzana
• Yambiro kune vanhu vane mamwe mamiriro ehutano
• Yambiro kune mamwe mapoka
• Tora sekurairwa
• Zvakakosha kufunga kwekutora clopidogrel
• General
• Kuchengetedza
• Kufamba
• Kuzvibata-manejimendi
• Kuchengetedzwa kwekliniki
• Mari dzakavanzika
• Kuwanika
• Pane here dzimwe nzira?

Pfungwa dzeclopidogrel

1. Clopidogrel yemuromo piritsi inowanikwa seyakajairika uye zita rezita zvinodhaka. Zita reBrand: Plavix.
2. Clopidogrel inongouya muchimiro chetablet yaunotora nemuromo.
3. Clopidogrel inoshandiswa kudzivirira kurwisa kwemoyo uye sitiroko. Iyo yakatemerwa kune vanhu vakamboita chirwere chemwoyo chazvino kana sitiroko, kana vane peripheral arterial chirwere (kutenderera kwakashata mumakumbo).

Chii chinonzi clopidogrel?

Clopidogrel piritsi yemuromo mushonga wekurapa uyo unowanikwa sezita rezita remushonga Plavix. Inowanikwawo seyakajairika mushonga. Generic zvinodhaka kazhinji zvinodhura zvakaderera pane iyo brand-zita vhezheni. Mune zvimwe zviitiko, vanogona kunge vasingawanikwe musimba rese kana mafomu sezita rezita remushonga.

Clopidogrel inongouya muchimiro chetablet yaunotora nemuromo.

Nei zvichishandiswa

Clopidogrel inoshandiswa kudzivirira kuwanda kweropa kana iwe uine kurwadziwa kwepfupa, chirwere chetsinga chirwere (kutenderera kwakashata mumakumbo ako), chirwere chemwoyo, kana sitiroko.

Mushonga uyu unogona kushandiswa sechikamu chemubatanidzwa mushonga. Izvi zvinoreva kuti ungangoda kuitora pamwe nemamwe madhiragi. Chiremba wako anozofunga kana iwe uchifanira kushandisa ichi chinwiwa nemimwe mishonga, yakadai seaspirini.

Inoshanda sei

Clopidogrel ndeyekirasi yemishonga inonzi platelet inhibitors kana thienopyridine kirasi inhibitors yeP2Y12 ADP platelet receptors. Kirasi yemishonga iboka remishonga inoshanda nenzira yakafanana. Iyi mishonga inowanzo shandiswa kurapa mamiriro akafanana.

Maplatelet masero eropa ayo anobatsira rako reropa kuvhara kazhinji. Clopidogrel inobatsira kudzivirira maplatelet kubva kunamira pamwechete. Izvi zvinovamisa kubva pakuumba kuwanda kweropa.

Clopidogrel mhedzisiro

Clopidogrel yemuromo piritsi inogona kukonzera zvinyoro kana zvakakomba mhedzisiro. Iri rinotevera runyorwa rine mamwe akakosha mhedzisiro mhedzisiro anogona kuitika uchitora clopidogrel. Rondedzero iyi haisanganisi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeclopidogrel, kana matipi ekuti ungagadzirise sei zvinonetsa divi mhedzisiro, taura nachiremba wako kana wemishonga.

Zvimwe zvakajairika mhedzisiro

Iyo yakajairika mhedzisiro mhedzisiro inogona kuitika ne clopidogrel inosanganisira:

• kubuda ropa
• ganda rinonhuwa

Kana iwe uine ganda rinonamira, rinogona kuenda mukati memazuva mashoma kana mavhiki mashoma. Kana yakanyanya kuoma kana kuti isingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira. Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Yakakomba, inotyisidzira hupenyu kubuda ropa. Zviratidzo zvinogona kusanganisira:
  • kubuda ropa zvisina tsananguro kana kubuda ropa zvinogara kwenguva refu
  • ropa mumuti wako (pink, tsvuku, kana mutsvuku-mutsvuku)
  • tsvuku kana zvitema zvituru zvinoita kunge tara
  • kusagadzikana kusinganzwisisiki kana kupwanywa kunowedzera
  • kukosora ropa kana kugwamba kweropa
  • kurutsa ropa kana kurutsa zvinoita kunge kofi nzvimbo
• Dambudziko rekuvhara ropa rinonzi thrombotic thrombocytopenic purpura (TTP). Aya mamiriro anogona kuitika mushure mekutora clopidogrel, kunyangwe kana iwe uchingoitora isingasviki mavhiki maviri. MuTTP, kuwanda kweropa kunoumba mumidziyo yeropa chero kupi mumuviri. Tora rubatsiro rwechiremba ipapo kana uine chimwe chezviratidzo izvi:
  • purplish mavara (purpura) paganda rako kana mumuromo mako (mucous membrane) nekuda kwekubuda ropa pasi peganda
  • kuchena kweganda rako kana kuchena kwemaziso ako (jaundice)
  • kuneta kana kushaya simba
  • ganda rakachenuruka
  • kupindwa nechando
  • kukurumidza kurova kwemoyo kana kupfupika kwemweya
  • musoro
  • kunetseka kutaura kana kunzwisisa mutauro (aphasia)
  • kuvhiringidzika
  • coma
  • sitiroko
  • pfari
  • weti shoma, kana weti iri pink kana ine ropa mukati
  • kurwadziwa nemudumbu
  • kusvotwa, kurutsa, kana kuita manyoka
  • kurasikirwa kwemaonero

Clopidogrel inogona kusangana nemimwe mishonga

Clopidogrel yemuromo piritsi inogona kusangana nemimwe mimwe mishonga. Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, vamwe vanogona kukanganisa mashandiro anoita mushonga, asi mamwe anogona kukonzera kuwedzera mhedzisiro.

Pazasi pane runyorwa rwemishonga inogona kusangana neclopidogrel. Urongwa urwu hauna mishonga yose inogona kuwirirana ne clopidogrel.

Usati watora clopidogrel, ita shuwa yekuudza chiremba wako uye wemishonga nezve zvese zvirevo, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Vaudzewo nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Chirwere cheshuga

Kazhinji, repaglinide haifanire kutorwa ne clopidogrel. Kutora iyi mishonga pamwe chete kunowedzera huwandu hwe repaglinide mumuviri wako, izvo zvinogona kukonzera huwandu hweshuga yeropa. Kana iwe uchifanira kutora madhiragi aya pamwe chete, chiremba wako achanyatso gadzirisa dosi yako ye repaglinide.

Dumbu acid mishonga (proton pump inhibitors)

Iwe haufanire kutora clopidogrel nemishonga inoshandiswa kurapa mudumbu acid. Ivo vanogona kuita kuti clopidogrel isanyanya kushanda. Mienzaniso yemishonga iyi inosanganisira:

• omeprazole
• esomeprazole

Nonsteroidal anti-anogumbura zvinodhaka (NSAIDs)

Kutora clopidogrel neNSAIDs kunogona kuwedzera njodzi yako yekubuda ropa mudumbu nemuura. Mienzaniso yemishonga iyi inosanganisira:

• asipurini
• ibuprofen
• naproxen

Ropa rakapfava

Warfarin uye clopidogrel inoshanda kutetepa ropa nenzira dzakasiyana. Kuvatora pamwe chete kunowedzera njodzi yako yekubuda ropa.

Zvinodhaka zvinoshandiswa kurapa kushushikana

Kushandisa zvimwe zvinodzvinyirira neclopidogrel kunogona kuwedzera njodzi yekubuda ropa. Mienzaniso yemishonga iyi inosanganisira:

• kusarudza serotonin reuptake inhibitors (SSRIs)
• serotonin-norepinephrine reuptake inhibitors (SNRIs)

Salicylates (asipurini)

Kana iwe uine acon coronary syndrome, iwe unofanirwa kutora aspirin neclopidogrel. Nekudaro, haufanire kutora mishonga iyi pamwechete kana iwe uchinge waita sitiroko ichangopfuura. Kuita izvi kunowedzera mukana wako wekubuda ropa zvakanyanya.

Opioid

Kutora mushonga weopioid neclopidogrel kunogona kunonoka kunwa uye kudzikisa huwandu hweclopidogrel mumuviri wako, zvichiita kuti isanyanya kushanda. Kana iwe uchifanira kutora mishonga iyi pamwechete, chiremba wako anogona kunyorera imwezve mishonga yekubatsira kudzivirira kugwamba kweropa mune mamwe mamiriro.

Mienzaniso yeopioid inosanganisira:

• codeine
• hydrocodone
• fentanyl
• morphine

Maitiro ekutora clopidogrel

Iyo clopidogrel muyero unorayirwa nachiremba wako zvinoenderana nemhando yemamiriro auri kushandisa mushonga kurapa.

Kazhinji, chiremba wako anokutanga iwe pane yakaderera dosi uye uigadzirise nekufamba kwenguva kuti usvike padosi yakakunakira iwe. Ivo pakupedzisira vanozopa diki diki iyo inopa iyo yaunoda mhedzisiro.

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu uye simba

Generic: Clopidogrel

• Fomu: piritsi remuromo
• Simba: 75 mg uye 300 mg

Brand: Plavix

• Fomu: piritsi remuromo
• Simba: 75 mg uye 300 mg

Chipimo chemushonga weacute coronary syndrome

Muyero wevakuru (makore gumi nemasere uye mukuru)

• Chaizvoizvo kutanga dosi: 300 mg, yakatorwa kamwe chete. Kutanga kurapwa pasina kurodha dosi kunononoka mhedzisiro nemazuva akati wandei.
• Maintenance chipimo chemushonga: 75 mg, inotorwa kamwe chete pazuva.

Chiyero chemwana (makore 0 kusvika 17 makore)

Mushonga uyu hausati wadzidzwa muvana uye haufanire kushandiswa muvanhu vadiki pane makore gumi nemasere.

Chipimo chemushonga wemwoyo uchangoburwa, sitiroko ichangoburwa, kana chirwere chepfungwa chekuparara

Muyero wevakuru (makore gumi nemasere uye mukuru)

• Chaicho chipimo chemushonga: 75 mg inotorwa kamwe pazuva.

Chiyero chemwana (makore 0 kusvika 17 makore)

Mushonga uyu hausati wadzidzwa muvana uye haufanire kushandiswa muvanhu vadiki pane makore gumi nemasere.

Clopidogrel yambiro

FDA Yambiro: Chiropa basa yambiro

• Mushonga uyu une Nhema Bhokisi Yambiro. Iyi ndiyo yambiro yakanyanya kubva kuFood and Drug Administration (FDA). Nyevero yebhokisi dema inozivisa vanachiremba nevarwere kune zvingangoitika zvine njodzi.
• Clopidogrel yakaputsika nechiropa chako. Vamwe vanhu vane magene ekusiyana kwekuti rimwe remakemikari echiropa, cytochrome p-450 2C19 (CYP2C19), rinoshanda sei. Izvi zvinogona kudzora kuti mushonga uyu wakaputsika sei mumuviri wako woita kuti usashande zvakare. Chiremba wako anogona kukuedza kuti aone kana iwe uine iyi geni mutsauko. Kana iwe unayo, chiremba wako achapa mamwe marapirwo kana madhiragi pane clopidogrel.

Nyevero yakakomba yekubuda ropa

Ichi chinodhaka chinogona kukonzera zvakakomba uye dzimwe nguva kuuraya kubuda ropa. Clopidogrel inogona kukuita kuti upwanya uye ubude ropa zviri nyore, uine kubuda ropa mumhino, uye zvinotora nguva yakareba kupfuura zvakajairika kuti kubuda ropa kumire. Iwe unofanirwa kutaurira chiremba wako nezve chero kubuda kwakakomba kweropa, senge:

• kusanzwisisika, kureba, kana kunyanyisa kubuda ropa
• ropa rako weti kana chigaro

Yambiro yekuvhiyiwa kana maitiro

Usati waitwa chero maitiro, iwe unofanirwa kutaurira vanachiremba vako kana vanachiremba vemazino kuti uri kutora clopidogrel. Iwe ungangoda kumira kutora ichi chinwiwa kwenguva pfupi pamberi penzira yekudzivirira kubuda ropa. Chiremba wako achakuzivisa iwe nguva yekurega kutora iyi mishonga uye kana zvakanaka kuitora zvakare.

Allergy yambiro

Clopidogrel inogona kukonzeresa kukonzeresa kukonzeresa. Zviratidzo zvinogona kusanganisira:

• kunetseka kufema
• kuzvimba kwechiso chako, miromo, rurimi, kana huro

Usatore mushonga uyu zvakare kana iwe wakambove neanegiriki maitiro kwairi. Iwe zvakare haufanire kutora uyu mushonga kana uri weergoria kune thienopyridines (senge ticlopidine uye clopidogrel). Kuitora kechipiri mushure mezvinhu zvinokanganisa muviri kunogona kuuraya.

Kudhakwa kudyidzana

Doro rinogona kuwedzera njodzi yako yekubuda ropa paunenge uchitora mushonga uyu.

Yambiro kune vanhu vane mamwe mamiriro ehutano

Kune vanhu vane ropa rinoshanda: Iwe haufanire kutora clopidogrel kana uine ropa rinoshanda (senge uropi hunobuda ropa) kana chirwere chinokonzeresa kubuda ropa (senge dumbu kana ura chironda). Clopidogrel inodzivirira kugwamba uye inowedzera njodzi yako yekubuda ropa.

Kune vanhu vane allergies kune thienopyridines: Kana iwe wakambove neyakagonana kugadzirisa kune chero rudzi rwe thienopyridine, haufanire kutora clopidogrel.

Kune vanhu vane sitiroko ichangoburwa: Iwe haufanire kutora uyu mushonga neasprini kana iwe uchangobva kuve nesitiroko. Inogona kuwedzera njodzi yako yekubuda ropa kwakanyanya.

Yambiro kune mamwe mapoka

Kune vakadzi vane pamuviri: Zvidzidzo zvakaitwa mumadzimai akazvitakura anotora clopidogrel hazvina kuratidza njodzi yakawedzera yekuremara kwekuberekwa kana kupererwa nemimba. Zvidzidzo zveclopidogrel mune mhuka dzine nhumbu zvakare hazvina kuratidza idzi njodzi.

Zvisinei, kune njodzi dzinogona kuitika kuna amai nemucheche kana chirwere chemwoyo kana sitiroko zvikaitika panguva yepamuviri. Naizvozvo, kubatsirwa kweclopidogrel mukudzivirira zviitiko zvehutano izvi kunogona kukunda chero njodzi yemushonga panhumbu.

Udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Clopidogrel inofanirwa kushandiswa panguva yekuzvitakura chete kana bhenefiti ingango ruramisa njodzi inogona kuitika.

Kune vakadzi vari kuyamwa: Hazvizivikanwe kana clopidogrel ichipinda mukaka wechipfuva. Kana zvikadaro, zvinogona kukonzera zvakakomba mumwana anoyamwa zamu. Iwe nachiremba wako mungangoda kusarudza kana muchizotora clopidogrel kana kuyamwisa.

Zvevana: Kuchengeteka uye kushanda kweclopidogrel hakuna kusimbiswa muvana vadiki pane makore gumi nemasere.

Tora sekurairwa

Clopidogrel piritsi yemuromo inoshandiswa kurapwa kwenguva refu. Iyo inouya nenjodzi dzakakomba kana iwe ukasazvitora sezvakarairwa.

Kana iwe ukarega kutora mushonga kana usinga utore zvachose: Iwe unowedzera njodzi yako yekurwadziwa kwemoyo kana sitiroko. Aya mamiriro anogona kuuraya.

Kana iwe uchifanira kumbomira kwenguva pfupi kutora clopidogrel, tanga kuitora zvakare nekukurumidza apo chiremba wako anokuudza iwe. Kumisa ichi chinodhaka kunogona kuwedzera njodzi yako yemamiriro ezvinhu akakomba emwoyo, kurohwa, kana kuvhara ropa mumakumbo kana mumapapu.

Kana iwe ukarasikirwa nemadhizaini kana usatore mushonga panguva yakatarwa: Mishonga yako inogona kusashanda zvakare kana kuti inogona kumira kushanda zvachose. Kuti mushonga uyu ushande zvakanaka, imwe nhanho inoda kuve mumuviri wako nguva dzose.

Kana iwe ukatora zvakawandisa: Iwe unogona kuve nenjodzi nhanho dzechirwere mumuviri wako. Zviratidzo zvekuwedzeredza kwechirwere ichi zvinogona kusanganisira kubuda ropa.

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako kana kutsvaga nhungamiro kubva kuAmerican Association of Poison Control Centers pa800-222-1222 kana kuburikidza nechavo online chishandiso Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Chii chaunofanira kuita kana ukarasikirwa nedosi: Kana iwe ukarasikirwa nedosi, tora clopidogrel nekukurumidza iwe pauchayeuka. Kana ingangoita nguva yedosi yako inotevera, ruka iro rakarasika. Tora dosi imwe chete panguva yako yenguva dzose. Usatora miviri miviri yeclopidogrel panguva imwechete kunze kwekunge chiremba wako akakuudza kuti uite.

Maitiro ekuudza kana mushonga uri kushanda: Iwe haufanire kunge uine chirwere chemwoyo kana sitiroko.

Zvakakosha kufunga kwekutora clopidogrel

Chengetedza izvi kufunga mupfungwa kana chiremba wako akaraira clopidogrel yemuromo piritsi kwauri.

General

• Usacheke kana kupwanya piritsi.

Kuchengetedza

• Chengetedza clopidogrel pakushambidza kwemukati padyo ne77 ° F (25 ° C). Inogona kuchengetwa kwenguva pfupi pane tembiricha iri pakati pe 59ºF uye 86 ° F (15ºC uye 30 ° C).
• Usachengetedze mushonga uyu munzvimbo dzine hunyoro kana nyorova, senge dzimba dzekugezera.

Kufamba

Paunenge uchifamba nemushonga wako:

• Nguva dzose takura mishonga yako newe. Paunenge uchibhururuka, usamboisa mubhegi rakaongororwa. Zvichengete muhomwe yako yekutakura.
• Usatombo kunetseka nezve airport X-ray michina. Hazvikanganisa mishonga yako.
• Ungangoda kuratidza vashandi vepanhandare yendege chitambi chemishonga yako. Nguva dzose takura mudziyo wepakutanga-wakanyorwa nemudziyo.
• Usaise mushonga uyu mugirovhosi remota yako kana kuusiya mumota. Ive neshuwa yekurega kuita izvi kana mamiriro ekunze ari kupisa kana kutonhora zvakanyanya.

Kuzvibata-manejimendi

Chiremba wako achakudzidzisa iwe uye nhengo dzemhuri yako zviratidzo zvekurwadziwa kwemoyo, kurohwa, kana kuvhara ropa mumakumbo ako kana mapapu. Kana iwe uine zviratidzo zvematambudziko aya, unofanirwa kuenda kuimba yekukurumidzira kana kufonera 911 ipapo ipapo.

Kuchengetedzwa kwekliniki

Usati watanga kurapwa neclopidogrel, chiremba wako anogona kuita genetiki yekutarisa yako CYP2C19 genotype. Iyi general test ichabatsira chiremba wako kusarudza kana uchifanira kutora clopidogrel. Mamwe magenotypes anononoka kuti clopidogrel yaputswa sei. Kana iwe uine rudzi urwu rwe genotype, uyu mushonga ungasashandira iwe.

Kuti uone kuti mishonga yako iri kushanda uye yakachengeteka kwauri, chiremba wako achaongorora zvinotevera:

• yakazara ropa kuverenga (CBC)
• zviratidzo zvekubuda ropa

Mari dzakavanzika

Kana iwe uri kurapwa kweacute coronary syndrome, iwe ungatofanira kutora clopidogrel ine aspirin. Chiremba wako anogona kukuudza zvakawanda.

Kuwanika

Mazhinji mafarmasi anoverengeka akajairika mafomu eclopidogrel. Nekudaro, kwete ese ma pharmacy anochengeta Plavix, iyo zita rezita-zita. Kana chiremba wako akaraira Plavix, paunenge uchizadza mushonga wako, ita shuwa yekufonera kumberi kuti uve nechokwadi chekuti pharmacy yako inoitakura.

Pane here dzimwe nzira?

Kune mimwe mishonga inowanikwa yekurapa mamiriro ako. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Taura nachiremba wako nezve dzimwe sarudzo dzemushonga dzinogona kukushandira.

Disiki: Healthline yaedza nepese painogona kuti ive nechokwadi chekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.