Harvoni (ledipasvir / sofosbuvir)

Zvemukati

• Chii chinonzi Harvoni?
• Harvoni generic
• Harvoni mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Kudzivirira kuzviuraya
• Yakareba-nguva mhedzisiro
• Zvikanganiso mushure mekurapwa
• Kurera huremu kana kuwedzera huremu
• Kurega zviratidzo
• Joint kurwadziwa
• Migumisiro yeziso
• Bvudzi kurasikirwa
• Rash / kurira
• Manyoka
• Kushungurudzika
• Kuneta
• Kusarara (kunetseka kurara)
• Kutemwa nemusoro
• Gomarara rechiropa / gomarara
• Harvoni mutengo
• Mari uye inishuwarenzi rubatsiro
• Harvoni anoshandisa
• Harvoni muyero
• Mafomu emishonga uye simba
• Chiyero chehepatitis C
• Nguva yekurapa
• Ko kana ndikapotsa dosi?
• Kunamatira kune yako Harvoni chirongwa chekurapa
• Harvoni uye doro
• Harvoni ine ribavirin
• Ribavirin mhedzisiro
• Ribavirin uye nhumbu
• Ribavirin uye kuyamwisa
• Harvoni kudyidzana
• Harvoni nemimwe mishonga
• Harvoni uye ribavirin
• Harvoni uye omeprazole kana mamwe maPPI
• Harvoni nemishonga uye zvinowedzera
• Harvoni nekofi
• Dzimwe nzira kuHarvoni
• Harvoni vs. mimwe mishonga
• Harvoni vs. Epclusa
• Harvoni vs. Mavyret
• Harvoni vs. Sovaldi
• Harvoni vs. Zepatier
• Maitiro ekutora Harvoni
• Nguva
• Kutora Harvoni nechikafu
• Inogona Harvoni kupwanywa here?
• Mashandiro anoita Harvoni
• Nezve hepatitis C
• Harvoni anorapa sei hepatitis C?
• Zvinotora nguva yakareba sei kuti zvishande?
• Harvoni uye nhumbu
• Harvoni nekuyamwisa
• Mibvunzo yakajairika nezveHarvoni
• Ini ndinofanira here kutevera yakakosha kudya ndichitora Harvoni?
• Inguva yakareba sei Harvoni achatora kubvisa hepatitis C yangu?
• Ndeupi mushonga weHarvoni?
• Ko hepatitis C inogona kudzoka mushure mekutora Harvoni?
• Chii chinonzi hepatitis C genotype?
• Harvoni kudarika
• Ovhadhozi zviratidzo
• Zvekuita kana ovhadhozi
• Harvoni yambiro
• FDA yambiro: Kugadzirisazve hutachiona hwehepatitis B
• Dzimwe yambiro
• Harvoni kupera
• Ruzivo rwehunyanzvi rweHarvoni
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengetedza

Chii chinonzi Harvoni?

Harvoni izita rezita rekushandisa mishonga yekurapa hepatitis C. Harvoni ine mishonga miviri: ledipasvir uye sofosbuvir. Iyo inouya sehwendefa iyo inowanzo kutorwa kamwe zuva nezuva kwevhiki gumi nembiri.

Harvoni rudzi rwemishonga inonzi yakananga-inoshanda antiviral (DAA). Yakagamuchirwa neDFA muna2014 kurapa genotypes dzakasiyana, kana mafomu, ehepatitis C.

Harvoni inobvumidzwa kurapa hepatitis C:

• mune vanhu vane hepatitis C genotypes 1, 4, 5, uye 6
• muvanhu vane kana vasina cirrhosis
• mune vanhu vakamboiswa chiropa
• muvanhu vakuru kana vana vane makore gumi nemaviri kana kupfuura kana vanorema angangoita makumi manomwe nemaviri mapaundi

Muzvidzidzo zvakawanda zvekiriniki zveHarvoni, iyo yekubudirira kwekuporesa hepatitis C yaive yakakura kupfuura makumi mapfumbamwe muzana. Izvi zvinoreva kuti vangangoita vanhu vese vakatora Harvoni vakawana yakagadziriswa virologic mhinduro (SVR). SVR zvinoreva kuti vanga vasina hutachiona hwakaonekwa mumuviri wavo mavhiki gumi nemaviri kana kupfuura mushure mekurapwa kwapera.

Harvoni generic

Harvoni ine mishonga miviri muhwendefa rimwe chete: ledipasvir uye sofosbuvir. Ikozvino parizvino hapana generic mafomu eanogona kusangana musanganiswa kana iwo wega madhiragi. Harvoni inongowanikwa chete sezita-zita mushonga mushonga.

Zvisinei, generic vhezheni yeHarvoni inotarisirwa kuburitswa kutanga kwa2019.

Harvoni mhedzisiro

Harvoni inogona kukonzera zvinyoro kana zvakakomba mhedzisiro. Iri rinotevera runyorwa rine mamwe akakosha mhedzisiro mhedzisiro anogona kuitika uchitora Harvoni. Rondedzero iyi haisanganisi mhedzisiro inogona kuitika.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeHarvoni kana matipi ekuti ungagadzirise sei nekushungurudza mhedzisiro, taura nachiremba wako kana wemishonga.

Kana chiremba wako achirairawo ribavirin kuti iwe utore naHarvoni, unogona kuve nemimwe mhedzisiro. (Ona "Harvoni uye ribavirin" pazasi.)

Zvimwe zvakajairika mhedzisiro

Iyo inowanzoitika mhedzisiro mhedzisiro yeHarvoni inogona kusanganisira:

• kuneta
• musoro
• kusvotwa
• manyoka
• kushaya hope (kunetseka kurara)
• kukosora
• kushaya simba
• kurwadziwa kwemhasuru
• dyspnea (kupfupika kwemweya)
• kugumbuka
• dzungu

Mune zvimwe zviitiko, Harvoni inogona kukonzeresa kugadzikana kweyeergic reaction. Zviratidzo zvinogona kusanganisira kuputika kweganda, kunhuwa, uye kupukuta (kudziya kweganda uye kutsvuka, kazhinji kumeso nemutsipa).

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana vhiki dzinoverengeka. Kana vakanyanya kuomarara kana vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Matambudziko akakomba kubva kuHarvoni haana kujairika, asi anogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Hepatitis B inogadzirisazve muvanhu vane hutachiona hwe hepatitis C uye hepatitis B. Vamwe vanhu vane hepatitis C uye hepatitis B vakaona kumutsidzirwa kwehutachiona hwe hepatitis B pavakatanga kurapwa naHarvoni. Kubata zvakare kunoreva kuti hutachiona hunotanga kushanda zvakare. Kugadziriswa kwehutachiona hwehepatitis B kunogona kutungamira kukuvara kwechiropa, kukundikana kwechiropa, kana kufa. Usati watanga kurapwa naHarvoni, chiremba wako achakuedza nezve hepatitis B. Ungangoda kutora mishonga yekurapa hepatitis B.
• Yakakomba sema maitiro. Muzviitiko zvisingawanzoitika, Harvoni inogona kukonzeresa kukonzeresa kukonzeresa. Zviratidzo zvinogona kusanganisira:
• angioedema (kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka)
• kuzvimba kwehuro, muromo, uye rurimi
• kunetseka kufema
• Pfungwa dzekuzviuraya. Muzviitiko zvisingawanzoitika, Harvoni inogona kukonzera pfungwa dzekuzviuraya kana zviito kana ikatorwa pamwe chete ne ribavirin kana pegylated interferon / ribavirin.

Kudzivirira kuzviuraya

• Kana iwe uchiziva mumwe munhu ari panjodzi yekukurumidza yekuzvikuvadza, kuzviuraya, kana kukuvadza mumwe munhu:
• Fonera 911 kana iyo yemuno emergency emergency.
• Gara nemunhu kusvikira rubatsiro rwehunyanzvi rwasvika.
• Bvisa chero zvombo, mishonga, kana zvimwe zvinogona kukuvadza zvinhu.
• Teerera kumunhu pasina kutonga.
• Kana iwe kana mumwe munhu waunoziva uine pfungwa dzekuzviuraya, nhare yekudzivirira inogona kubatsira. National Suicide Prevention Lifeline inowanikwa maawa makumi maviri nemana pazuva pa1-800-273-8255.

Yakareba-nguva mhedzisiro

Yenguva refu-mhedzisiro mhedzisiro haina kutaurwa nekushandiswa kweHarvoni.

Zvisinei, vanhu vane cirrhosis (chiropa chinopisa) vanogona kuramba vaine zviratidzo zvekukuvara kwechiropa mushure mekunge hepatitis C yaporeswa. Kana iwe uine cirrhosis, chiremba wako achada kutarisa chiropa chako chinoshanda nguva dzose panguva uye mushure mekurapa naHarvoni.

Zvikanganiso mushure mekurapwa

Zvimwe zvinokanganisa mushure mekurapa kweHarvoni hazvina kutaurwa muzvidzidzo zvekiriniki.

Nekudaro, mushure mekupedza kurapwa naHarvoni, vamwe vanhu vanogona kuve nezviratidzo zvakaita sefuru, senge mhasuru aches, chills, kuneta, uye kunetseka kurara. Iyi mhedzisiro inogona kukonzerwa nemuviri wako kupora mushure mekubviswa kwehutachiona hwehepatitis C.

Kana iwe uine zviratidzo zvakaita sefuru mushure mekupedza kurapwa naHarvoni, taura nachiremba wako.

Kurera huremu kana kuwedzera huremu

Kuchinja kwehuremu panguva yekurapwa kweHarvoni hakuna kutaurwa muzvidzidzo zvekiriniki. Zvisinei, vamwe vanhu vakarasikirwa nehuremu sechiratidzo chehepatitis C. Kana iwe uchinge uchinja zvakanyanya pahuremu, taura nachiremba wako.

Kurega zviratidzo

Kumisa kurapwa naHarvoni hakuna kukonzera zviratidzo zvekudzoka muzvidzidzo zvekiriniki.

Vamwe vanhu vanogona kuona zviratidzo zvinoita sekusiya, senge furuu-yakaita sefivha, kurwadziwa nemusoro, uye kurwadziwa nemhasuru. Zvisinei, hazvina kujeka kana zviratidzo izvi zvine chekuita nekumisa kurapwa kweHarvoni.

Joint kurwadziwa

Joint kurwadziwa kwanga kusiri kweimwe divi mhedzisiro yeHarvoni mune zvekuchipatara zvidzidzo.

Vanhu vazhinji vane hepatitis C vanonzwa kurwadziwa pamwe chete sechiratidzo chehutachiona, zvakadaro. Izvi zvinogona kuve mugumisiro wekusingaperi kuzvimba kana autoimmune maitiro ekurwisa majoini ako.

Kana iwe uchirwadziwa mumajoini ako, taura nachiremba wako nezvenzira dzekuzvibata.

Migumisiro yeziso

Mune kiriniki zvidzidzo zveHarvoni, vanhu vanotora mushonga havana kusangana nematambudziko eziso. Asi pane mumwe mushumo wekuona kwenguva pfupi kurasikirwa mushure mekushandisa Harvoni nemushonga ribavirin. Uye mumwe munhu akataura kuzvimba kwemaziso uye kuona kwakashata mushure mekushandisa sofosbuvir (mumwe wemishonga muHarvoni) uye ribavirin.

Zvisinei, hazvisi pachena kana Harvoni kana zvigadzirwa zvayo zvakakonzera matambudziko emaziso mune aya kesi. Zvakare, ongororo ye2019 yakawana kuti iyi mimwe mishonga haina kukonzera matambudziko emaziso kune vanhu vane hepatitis C.

Chero zvazvingaitika, kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchitora Harvoni, taura nachiremba wako ipapo ipapo.

Bvudzi kurasikirwa

Kurasikirwa kwebvudzi hakuna kutaurwa semhedzisiro mhedzisiro muzvidzidzo zvekiriniki zveHarvoni. Vamwe vanhu vakataura vachirasikirwa nevhudzi vachitora mushonga, asi hazvisi pachena kana Harvoni yaive honzeri yebvudzi ravo.

Zvakakosha kucherechedza kuti kurasikirwa nevhudzi kunogona kuva chiratidzo chehepatitis C. Hepatitis C virus (HCV) inodzivirira chiropa chako kushanda nemazvo. Unoda chiropa chine hutano kuti uwane zvinovaka muviri kubva pane chikafu chaunodya. Saka kana iwe usingakwanise kuwana zvinovaka muviri izvo muviri wako unoda, unogona kuwana kurasikirwa nevhudzi.

Kana iwe uine hanya nezvekurasikirwa kwebvudzi, taura nachiremba wako.

Rash / kurira

Kuputika kweganda kwakataurwa mune vamwe vanhu vakatora Harvoni muzvidzidzo zvekiriniki, asi hazvizivikanwe kuti vanga vakajairika sei. Mune zvimwe zviitiko, vanhu vaive nemabhuru uye kuzvimba kweganda, futi. Izvi zvinogona kukonzereswa neanogadzirisa maitiro kuHarvoni.

Ganda rinotsemuka uye mapundu zvakare zviratidzo zvehutachiona hwe hepatitis C. Uye zvakare, vanogona kuve zviratidzo zvekukuvara kwechiropa kwakakomba. Taura nachiremba wako kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchida.

Manyoka

Mune kiriniki zvidzidzo zveHarvoni, pakati pe3 muzana uye 7 muzana yevanhu vakasangana nemanyoka panguva yekurapwa. Dhairrhea inogona kuenda nekuenderera mberi nekushandisa kwechirwere.

Kana iwe uine manyoka akakomba, kana manyoka ayo anogara anopfuura mazuva mashoma, taura nachiremba wako ipapo ipapo.

Kushungurudzika

Kushungurudzika chinhu chisingawanzoitika mhedzisiro yeHarvoni. Mune zvidzidzo zvemakiriniki, pasi pe5 muzana yevanhu vakatora Harvoni vakaora mwoyo. Uye zvakare, pfungwa dzekuzviuraya dzakaitika mune isingasviki 1 muzana yevanhu vakatora Harvoni ne ribavirin kana pegylated interferon / ribavirin.

Vanhu vazhinji vane hepatitis C vanogona kunzwa kuora mwoyo nekuda kwekuziva kwavo. Kana iwe uchinzwa kuora mwoyo, taura nachiremba wako nezvenzira dzekuvandudza mafungiro ako. Uye kana iwe uine pfungwa dzekuzvikuvadza iwe, dana chiremba wako ipapo ipapo.

Kuneta

Kuneta, kana kushomeka kwesimba, ndizvo zvakajairika mhedzisiro yeHarvoni. Muzvidzidzo zvekiriniki, vanosvika 18 muzana yevanhu vakatora Harvoni vakasangana nokuneta.

Kuneta kunogona kuenda nekuenderera mberi nekushandisa Harvoni. Zvisinei, kana kuneta kwako kwakanyanya uye kuchikanganisa hupenyu hwako, taura nachiremba wako.

Kusarara (kunetseka kurara)

Muzvidzidzo zvemakiriniki, kushaya hope kwakaitika kusvika pa6 muzana yevanhu vakatora Harvoni. Iyi divi mhedzisiro inogona kuenda nekuenderera mberi nekushandisa kwechirwere.

Nzira dzekuvandudza hope dzako dzinosanganisira kutevedzera nguva yekurara uye kuchengeta zvemagetsi, zvakaita semafoni efoni, kunze kweimba yako yekurara. Kana kusarara kwako kuchikunetsa uye kukasaenda, taura nachiremba wako nezve dzimwe nzira dzekukubatsira kurara.

Kutemwa nemusoro

Musoro wemusoro unowanzoitika mhedzisiro yeHarvoni. Muzvidzidzo zvekiriniki, vanosvika makumi maviri nemapfumbamwe muzana yevanhu vakatora Harvoni vakasangana nemusoro. Kana iwe uchirwadziwa nemusoro uchitora Harvoni, taura nachiremba wako nezvenzira dzekukubatsira iwe kudzidzora.

Gomarara rechiropa / gomarara

Harvoni mushonga unonzi wakananga-kuita antiviral (DAA). Kurapa hepatitis C nemaDAA kunobatsira kudzivirira kwenguva refu mhedzisiro, senge kenza yechiropa. Nekudaro, kwakave nemishumo yekenza yechiropa muvanhu vakaporeswa hepatitis C pamwe neHarvoni kurapwa.

Imwe kiriniki yekudzidza yakawana kuti vanhu vane cirrhosis avo vakarapwa neDAA vaive nenjodzi yakakura yekuva nekenza yechiropa kana ichienzaniswa nevaya vasina cirrhosis. Nekudaro, vanhu vasina cirrhosis vanogona kuwana kenza yechiropa.

Kana iwe uine hanya nenjodzi yako yekuva nekenza yechiropa, taura nachiremba wako.

Harvoni mutengo

Sezvo nemishonga yese, mutengo weHarvoni unogona kusiyana.

Mari yako chaiyo inoenderana neinishuwarenzi yako yekuvhara.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Harvoni, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidza, rubatsiro rwuripo.

Gilead Sciences, Inc., iyo inogadzira Harvoni, inopa chirongwa chinonzi Harvoni Support Path. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fonera 855-769-7284 kana shanyira iyo webhusaiti chirongwa.

Harvoni anoshandisa

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saHarvoni kurapa mamwe mamiriro.

Harvoni is FDA-inogamuchirwa yekurapa hepatitis C hutachiona (HCV). Harvoni inogona kupihwa kune:

• Vakuru nevana (vane makore gumi nemaviri zvichikwira kana vanorema anosvika mapaundi makumi manomwe nenomwe) avo:
• vane HCV genotype 1, 4, 5, kana 6. Genotypes imhando dzakasiyana, kana mhando, dzehutachiona.
• vane kana vasina kubhadhara cirrhosis. Cirrhosis yakakomba kukuvara muchiropa kunotitadzisa kushanda nemazvo. Yakabhadharwa cirrhosis ndeye cirrhosis iyo kazhinji isingakonzere zviratidzo.
• Vakuru vano:
• vane genotype 1 uye yakaora cirrhosis. Yakagadziriswa cirrhosis ndipo apo chiropa chiri kutadza uye zvichikonzera zvakakomba hutano nyaya. Vanhu vane decompensated cirrhosis vanofanirwa kutora Harvoni nemushonga wechipiri, ribavirin (Rebetol).
• vane genotype 1 kana 4 uye vakave nechiropa chekuisa.

Iyi tafura inoratidza uyo anokodzera kurapwa kweHarvoni:

Harvoni muyero

Harvoni inorayirwa seyero imwe chete: Hwendefa rine 90 mg ye ledipasvir uye 400 mg yesofosbuvir, inotorwa kamwe pazuva.

Mune mamwe mamiriro ezvinhu, chiremba wako anogona kunyorera wechipiri mushonga kuti utore naHarvoni. Semuenzaniso, unogona kunyorerwa ribavirin (Rebetol) pamwe chete naHarvoni.

Izvi zvinogona kuitika kana iwe wakadzora cirrhosis (yakanyanya zviratidzo kubva pachiropa chakakwira chirwere) kana kana iwe wakatora mimwe mishonga yekurapa hepatitis C munguva yakapfuura. Yako ribavirin muyero inoenderana nehuremu hwako, kushanda kweitsvo, uye mamwe mamiriro ehutano.

Ruzivo runotevera runotsanangura chiyero chakakurudzirwa cheHarvoni.

Mafomu emishonga uye simba

Harvoni inowanikwa mune rimwe simba. Iyo inouya mune yakasanganiswa piritsi ine 90 mg ye ledipasvir uye 400 mg ye sofosbuvir.

Chiyero chehepatitis C

Muyero wekurapa hepatitis C ipiritsi rimwe (90 mg ledipasvir / 400 mg sofosbuvir), inotorwa kamwe chete pazuva.

Nguva yekurapa

Inguva yakareba sei iwe yaunotora Harvoni inoenderana neako hepatitis C genotype (strain yehutachiona). Izvo zvakare zvinoenderana neako chiropa mashandiro, uye chero hepatitis C kurapa iwe wawakaedza munguva yakapfuura.

Vazhinji vanhu vanotora Harvoni kwemavhiki gumi nemaviri, asi kurapwa kunogona zvakare kupedza masvondo masere kana makumi maviri nemana. Chiremba wako anoona nguva chaiyo yekurapa iwe.

Ko kana ndikapotsa dosi?

Izvo zvakakosha kutora Harvoni zuva rega rega kune iyo yakazara nguva yenguva iyo chiremba wako anoraira. Kupotsa kana kusvetuka madhizaini kunogona kukonzera hutachiona kusagadzikana neHarvoni. Kuramba zvinoreva kuti mushonga wacho hauchashandi kwauri.

Kushandisa chiyeuchidzo chishandiso kunogona kukubatsira iwe kurangarira kutora Harvoni mazuva ese.

Kana iwe ukarasikirwa neiyo dose, tora iyo nekukurumidza sezvaunoyeuka. Kana iwe ukasarangarira kusvikira zuva rinotevera, usatora miviri miviri yeHarvoni kamwechete. Izvi zvinogona kuwedzera njodzi yemhedzisiro. Ingo tora yako yenguva dzose dhizaini yeHarvoni.

Kunamatira kune yako Harvoni chirongwa chekurapa

Zvakakosha zvakanyanya kuti utore mapiritsi ako eHarvoni chaizvo sekurairwa nachiremba wako. Izvi zvinodaro nekuti kutevera chirongwa chako chekurapa kunowedzera mikana yako yekurapa hepatitis C yako (HCV). Izvo zvinobatsirawo kudzikisa njodzi yako yemhedzisiro-yenguva refu mhedzisiro yeHCV, iyo inosanganisira cirrhosis uye kenza yechiropa.

Kushaya madosi kunogona kuita kuti Harvoni isanyanya kushanda pakurapa HCV yako. Mune zvimwe zviitiko, kana ukarasikirwa nemadhizaini, HCV yako inogona kusapora.

Ive neshuwa yekutevera zvirevo zvechiremba wako uye tora imwe yeHarvoni piritsi zuva rega rega kwehurefu hwakazara hwekurapa kwako. Kushandisa chiyeuchidzo chishandiso kunogona kukubatsira iwe kuona kuti iwe unotora Harvoni zuva rega rega.

Kana iwe uine chero mibvunzo kana zvinonetsa nezvekurapa kwako, taura nachiremba wako. Vanogona kubatsira kugadzirisa chero nyaya kwauri uye nekukubatsira iwe kuti uwane kurapwa kwakanyanya kune yako hepatitis C.

Harvoni uye doro

Kunwa doro uchitora Harvoni kunogona kuwedzera njodzi yemamwe mhedzisiro kubva kuHarvoni. Iyi mhedzisiro inosanganisira:

• kuneta
• musoro
• kusvotwa
• manyoka

Uye zvakare, zvese hepatitis C uye kunyanya kushandisa doro zvinokonzeresa kukuvara uye kuzvimba muchiropa chako. Kubatanidza izvo zviviri kunowedzera mukana wako wecirrhosis uye kutadza kwechiropa.

Doro rinogona zvakare kukuita kuti usakwanise kutora mishonga yako sekurairwa nachiremba wako. Semuenzaniso, zvinogona kukonzera kuti ukanganwe kutora mishonga yako panguva yakakodzera. Kushaya madosi eHarvoni kunogona kuita kuti isanyanya kushanda pakurapa HCV yako.

Nezvikonzero zvese izvi, unofanirwa kudzivirira kunwa doro kana uine hepatitis C. Izvi zvinonyanya kuitika kana uchirapwa naHarvoni. Kana iwe uchinetseka kudzivirira doro, taura nachiremba wako.

Harvoni ine ribavirin

Harvoni inowanzo kutorwa iri yoga kurapa hepatitis C. Zvisinei, mune dzimwe nguva, inotorwa nemumwe mushonga unonzi ribavirin (Rebetol).

Chiremba wako anogona kunyorera ribavirin naHarvoni kana iwe:

• vane decompensated cirrhosis
• ndakave nekuiswa kwechiropa
• vasina kubudirira kurapwa pamwe nemimwe mishonga yehepatitis C munguva yakapfuura

Harvoni uye ribavirin zvinoshandiswa pamwechete muvanhu vari mumamiriro ezvinhu aya nekuti kiriniki zvidzidzo zvakaratidza mwero wepamusoro wekuporesa pamwe nekubatana kurapwa pane neHarvoni chete.

Kurapa ne ribavirin kazhinji kunotora vhiki gumi nembiri. Ribavirin inouya sepiritsi iwe yaunonwa kaviri pazuva. Muyero waunotora unozoenderana nehuremu hwako. Iyo inogona zvakare kuve yakavakirwa pane yako itsvo basa uye hemoglobin mazinga.

Ribavirin mhedzisiro

Ribavirin inogona kukonzera akati wandei zvakajairika uye zvakakomba mhedzisiro. Izvo zvinouyawo neyambiro dzakakosha.

Nyevero yebhokisi

Ribavirin ine yambiro yebhokisi kubva kuDAA. Nyevero yebhokisi ndiyo yakasimba mhando yambiro iyo iyo FDA inoda. Ribavirin yambiro yemabhokisi inopa zano kuti:

• Ribavirin haifanire kushandiswa yega kurapa hepatitis C nekuti haina kushanda pachayo.
• Ribavirin inogona kukonzera chirwere cheropa chinonzi hemolytic anemia. Aya mamiriro anogona kutungamira kurwara kwemoyo kana kufa. Nekuda kwenjodzi iyi, vanhu vane chirwere chakakomba kana chisina kugadzikana chemwoyo havafanirwe kutora ribavirin.
• Kana ribavirin ikashandiswa mumadzimai ane nhumbu, inogona kukonzera kukuvara kwakakomba kana kufa kumucheche. Ribavirin haifanire kutorwa nevakadzi vane nhumbu kana varume vavo vepabonde panguva yepamuviri. Kubata pamuviri kunofanirawo kudzivirirwa kwemwedzi mitanhatu mushure mekurapwa kweRibavirin. Munguva ino, funga kushandisa nzira yekuchengetedza dziviriro (kuzvarwa).

Mimwe mhedzisiro

Ribavirin inogona zvakare kukonzera zvimwe zvinowanzoitika mhedzisiro, senge:

• kuneta
• kunzwa kunetseka
• kupindwa nechando
• musoro
• kunzwa kushatirwa
• kurasikirwa nenzara
• kurwadziwa kwemhasuru kana kushaya simba
• kusvotwa
• kurutsa

Kazhinji asi zvakakomba mhedzisiro inoonekwa muzvidzidzo zvekiriniki zvaisanganisira kupererwa neropa, chirwere chemapapu, uye pancreatitis. Ivo zvakare vaisanganisira matambudziko emaziso, akadai sehutachiona uye kuona kwakasviba.

Ribavirin uye nhumbu

Ona "Nyevero yakaiswa mubhokisi" pamusoro.

Ribavirin uye kuyamwisa

Hazvizivikanwe kana ribavirin ichipinda mumukaka wemukaka wemunhu. Zvidzidzo mumhuka zvinoratidza kuti ribavirin inotorwa naamai inogona kukuvadza kuyamwisa vadiki. Zvisinei, zvidzidzo zvemhuka hazviwanzo kufanotaura zvichaitika muvanhu.

Kana iwe uri kufunga nezve ribavirin kurapwa paunenge uchiyamwa, taura nachiremba wako. Ivo vanogona kukurudzira kuti iwe urege kumira kuyamwisa kana kudzivirira ribavirin kurapwa.

Harvoni kudyidzana

Harvoni inogona kudyidzana nemimwe mishonga yakati wandei. Inogona zvakare kudyidzana nezvimwe zvinowedzera uye zvekudya.

Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, vamwe vanogona kukanganisa mashandiro anoita mushonga, asi mamwe anogona kukonzera kuwedzera mhedzisiro.

Harvoni nemimwe mishonga

Pazasi pane runyorwa rwemishonga inogona kusangana naHarvoni. Urongwa urwu hauna mishonga yose inogona kuwirirana naHarvoni.

Usati watora Harvoni, ita shuwa yekuudza chiremba wako uye wemishonga nezve zvese zvirevo, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Vaudzewo nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Antacids

Kutora Harvoni neantacids, senge Mylanta kana Tums, kunogona kudzikisa huwandu hweHarvoni muviri wako unotora. Izvi zvinogona kuita kuti Harvoni isanyanya kushanda. Kuti udzivise kudyidzana uku, paradzanisa muyero weHarvoni nemishonga inorwisa maaccid nemaawa mana.

H2 blockers

Kutora Harvoni nemishonga inonzi H2 blockers kunogona kudzikisa huwandu hweHarvoni inopinzwa mumuviri wako. Izvi zvinogona kukonzera kuti Harvoni isanyanya kushanda pakurwisa hutachiona hweH hepatitis C.

Kana iwe uchida kutora H2 blocker neHarvoni, iwe unofanirwa kuitora panguva imwe chete kana kuitora iwo gumi nemaviri maawa akasiyana. Kuzvitora panguva imwe chete kunoita kuti mishonga inyungudike uye inyurwe nemuviri wako zvisati zvaitika muH2 blocker yapinda. Kuvatora kwemaawa gumi nemaviri kupatsanurana zvakare kunotendera mushonga wega wega kuti unwe nemuviri wako usingawirirane nemumwe mushonga.

Mienzaniso yeH2 blockers inosanganisira famotidine (Pepcid) uye cimetidine (Tagamet HB).

Amiodarone

Kutora Harvoni ne amiodarone (Pacerone, Nexterone) kunogona kukonzera njodzi yekunonoka kwemoyo, iyo inonzi bradycardia. Mimwe mishumo yakataura kuti vanhu vakatora amiodarone naHarvoni pamwechete vaida pacemaker kuti varambe vachirova moyo nguva dzose. Vakaudzawo kuti vamwe vanhu vane chirwere chemwoyo chinouraya.

Kutora amiodarone neHarvoni pamwechete hazvikurudzirwe. Kana iwe uchifanira kutora Harvoni uye amiodarone pamwechete, chiremba wako anonyatsoongorora moyo wako mashandiro.

Digoxin

Kutora Harvoni ne digoxin (Lanoxin) kunogona kuwedzera huwandu hwe digoxin mumuviri wako. Digoxin mazinga akakwirira zvakanyanya anogona kutungamira kune ane njodzi mhedzisiro.

Kana iwe uchida kutora Harvoni uye digoxin pamwechete, chiremba wako anonyatso tarisa ako digoxin mazinga. Vanogona kushandura yako digoxin dose kudzikisa njodzi yemhedzisiro.

Kutora mishonga

Kutora Harvoni nemimwe mishonga yekubvuta kunogona kudzikisa huwandu hweHarvoni muviri wako unotora. Izvi zvinogona kudzikisira kushanda kweHarvoni. Neichi chikonzero, haufanire kutora Harvoni nemishonga yekubata iyi.

Mienzaniso yekutora mishonga yekudzivirira uchitora Harvoni inosanganisira:

• carbamazepine (Carbatrol, Equetro, Tegretol)
• phenytoin (Dilantin, Phenytek)
• phenobarbital
• oxcarbazepine (Trileptal)

Mishonga inorwisa mabhakitiriya

Mimwe mishonga inorwisa mabhakitiriya inogona kudzikisa mazinga eHarvoni mumuviri wako. Izvi zvinogona kuita kuti Harvoni isanyanya kushanda. Kuti udzivise kudyidzana uku, dzivisa kutora Harvoni nemishonga inotevera inorwisa mabhakitiriya.

• rifabutin (Mycobutin)
• rifampin (Rifadin, Rimactane)
• rifapentine (Priftin)

Mishonga yeHIV

Kutora Harvoni nemimwe mishonga yeHIV kunogona kuchinja mwero wemuviri wako weHarvoni kana mishonga yeHIV. Uku kudyidzana kunogona kuita kuti mishonga isanyanya kushanda kana kuwedzera njodzi yako yemhedzisiro.

Tenofovir disoproxil fumarate

Kutora Harvoni nemishonga ine tenofovir disoproxil fumarate inogona kuwedzera mwero we tenofovir mumuviri wako. Izvi zvinowedzera njodzi yemhedzisiro kubva kune tenofovir, sekukuvara kweitsvo. Kana iwe uchida kutora Harvoni nemishonga ine tenofovir disoproxil fumarate, chiremba wako anozokutarisa zvakanyanya padhuze nemhedzisiro.

Mienzaniso yemishonga ine tenofovir disoproxil fumarate inosanganisira:

• tenofovir (Viread)
• tenofovir uye emtricitabine (Truvada)
• tenofovir, elvitegravir, cobicistat, uye emtricitabine (Stribild)
• tenofovir, emtricitabine, uye rilpivirine (Complera)

Tipranavir uye ritonavir

Kutora Harvoni nemishonga yeHIV tipranavir (Aptivus) kana ritonavir (Norvir) kunogona kudzikisa huwandu hweHarvoni mumuviri wako. Izvi zvinogona kuita kuti Harvoni isanyanya kushanda. Kutora Harvoni netipranavir uye ritonavir haina kukurudzirwa.

Mishonga yecholesterol

Kutora Harvoni nemishonga yecholesterol inonzi ma statins kunogona kuwedzera iwo mazinga e statins mumuviri wako. Izvi zvinowedzera mukana wako we statin mhedzisiro, senge kurwadziwa kwemhasuru uye kukuvara.

Statins dzinosanganisira zvinodhaka senge rosuvastatin (Crestor), atorvastatin (Lipitor), uye simvastatin (Zocor). Kana iwe ukatora Harvoni ne statin, chiremba wako anozokutarisa zvakanyanya pazviratidzo zve rhabdomyolysis (kuputsika kwemhasuru).

Rosuvastatin naHarvoni havafanirwe kutorwa pamwechete. Mamwe ma statin anofanirwa kushandiswa nekuchenjerera naHarvoni.

Warfarin

Harvoni inogona kukanganisa kugona kwemuviri wako kuumba maopa clots. Kana iwe uchida kutora warfarin (Coumadin) paunenge uchirapwa naHarvoni, chiremba wako anogona kuyedza ropa rako kazhinji. Ivo vanogona zvakare kuda kuwedzera kana kudzikisa yako warfarin dose.

Harvoni uye ribavirin

Iko hakuna kudyidzana pakati peHarvoni uye ribavirin (Rebetol). Harvoni yakachengeteka kutora ne ribavirin. Muchokwadi, Harvoni inogamuchirwa neiyo FDA kutorwa ne ribavirin kune vanhu vane zvimwe nhoroondo dzezvekurapa.

Chiremba wako anogona kukunyorera ribavirin kuti iwe utore naHarvoni kana iwe:

• vane decompensated cirrhosis
• ndakave nekuiswa kwechiropa
• vakakundikana kurapwa nemamwe mishonga yehepatitis C munguva yakapfuura

Harvoni uye ribavirin zvinoshandiswa pamwechete muvanhu vane mamiriro aya nekuti zvidzidzo zvemakiriniki zvakaratidza mwero wepamusoro wekuporesa pamwe nemubatanidzwa mushonga.

Harvoni uye omeprazole kana mamwe maPPI

Kutora Harvoni ne omeprazole (Prilosec) kana imwe proton pump inhibitors (PPIs) kunogona kudzikisa huwandu hweHarvoni mumuviri wako. Izvi zvinogona kuita kuti Harvoni isanyanya kushanda.

Kana zvichibvira, dzivisa kutora Harvoni nekirasi iyi yemishonga. Kana iwe uchida PPI paunenge uchitora Harvoni, iwe unofanirwa kutora Harvoni uye iyo PPI panguva chaiyo yakafanana padumbu risina chinhu.

Mienzaniso yemamwe maPPI anosanganisira:

• esomeprazole (Nexium)
• Lansoprazole (Prevacid)
• pantoprazole (Protonix)

Harvoni nemishonga uye zvinowedzera

Kutora Harvoni neSt. John's wort kunogona kudzikisa huwandu hweHarvoni mumuviri wako. Izvi zvinogona kuita kuti Harvoni isanyanya kushanda. Kuti udzivise kudyidzana uku, usatora Harvoni neSt.

Mimwe miriwo kana zvinowedzera izvo zvinogona kudzikisa huwandu hweHarvoni mumuviri wako zvinosanganisira:

• kava kava
• mukaka munzwa
• aloe
• glucomannan

Munguva yekurapa kwako naHarvoni, bvunza nachiremba wako usati watora chero matsva matsva kana ekuwedzera.

Harvoni nekofi

Iko hakuna kutaurirana kwakataurwa pakati peHarvoni nekofi. Zvisinei, mamwe emigumisiro yeHarvoni inogona kuwedzerwa kana iwe ukadya kofi yakawandisa kana caffeine. Semuenzaniso, kunwa kofi masikati kana manheru kunogona kuita kuti matambudziko ako ekurara awedzere. Uye caffeine inogona kukuvadza musoro.

Kana iwe uchinwa kofi kana kudya caffeine nguva dzose, taura nachiremba wako nezvekuti kana izvi zvakachengeteka kwauri panguva yekurapwa kwako naHarvoni.

Dzimwe nzira kuHarvoni

Mimwe mishonga iripo inogona kurapa hepatitis C. Mimwe inogona kunge yakakunakira iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeHarvoni, taura nachiremba wako kuti udzidze zvakawanda nezvemimwe mishonga inogona kukushandira zvakanaka.

Hepatitis C inogona kurapwa uchishandisa mimwe mishonga yakawanda kana kusanganiswa kwemishonga. Mushonga wekurapa uyo chiremba wako waanosarudzira iwe unoenderana neephepatitis C genotype yako, chiropa chako chinoshanda, uye kuti wakagamuchira kurapwa kwehepatitis C here munguva yakapfuura.

Mienzaniso yemimwe mishonga inogona kushandiswa kurapa hepatitis C inosanganisira:

• Epclusa (velpatasvir, sofosbuvir)
• Mavyret (glecaprevir, pibrentasvir)
• Viekira Pak (paritaprevir, ombitasvir, ritonavir, dasubuvir)
• Vosevi (velpatasvir, sofosbuvir, voxilaprevir)
• Zepatier (elbasvir, grazoprevir)
• Rebetol (ribavirin), iyo inoshandiswa musanganiswa nemimwe mishonga

Interferon mishonga yekare iyo yaimboshandiswa kurapa hepatitis C. Zvisinei, mishonga mitsva yakadai saHarvoni inokonzeresa mhedzisiro uye ine huwandu hwakanyanya hwekurapa kupfuura interferon. Nezvikonzero izvi, nhasi interferon haiwanzoshandiswa kurapa hepatitis C.

Harvoni vs. mimwe mishonga

Unogona kushamisika kuti Harvoni anofananidzwa sei nemimwe mishonga inorayirwa kuti ishandiswe zvakafanana. Pazasi pane kuenzanisa pakati peHarvoni nemimwe mishonga.

Harvoni vs. Epclusa

Harvoni ine mishonga miviri mupiritsi imwe: ledipasvir uye sofosbuvir. Epclusa zvakare ine mishonga miviri mupiritsi imwe: velpatasvir uye sofosbuvir.

Mishonga yese iri miviri ine mushonga sofosbuvir, iyo inonzi "musana" wekurapa. Izvi zvinoreva kuti chirongwa chekurapa chinoenderana nemushonga wemusana, nemimwe mishonga inowedzerwa pamwe chete.

Zvishandiso

Harvoni naEpclusa vese FDA-inogamuchirwa kurapa hepatitis C. Harvoni inogona kurapa hepatitis C genotypes 1, 4, 5, uye 6, nepo Epclusa inogona kubata ese matanhatu genotypes.

Ose madhiragi anotenderwa kurapa vanhu vasina cirrhosis, kana nekuripa kana kudzora cirrhosis. Pane misiyano mishoma mune yavakatemerwa, zvichienderana negenotype, chiropa chinoshanda, uye nhoroondo yezvokurapa.

Harvoni is FDA-inogamuchirwa kurapa hepatitis C muvana vane makore gumi nemaviri zvichikwira kana vanorema anosvika makumi manomwe nemaviri mapaundi. Epclusa haina kubvumidzwa kurapa hepatitis C muvana.

Mafomu emishonga uye manejimendi

Harvoni naEpclusa vese vanotorwa sehwendefa rimwe chete zuva nezuva. Vanogona kutorwa nechikafu kana padumbu risina chinhu.

Iyo nguva yekurapwa kweHarvoni ingangoita masere, gumi nemaviri, kana makumi maviri nemana masvondo. Inguva yakareba sei iwe yaunotora Harvoni inoenderana neyako genotype, kana rudzi rwehepatitis C uye chiropa chako chinoshanda. Izvo zvakare zvinotenderera pane yako yapfuura hepatitis C kurapwa.

Iyo nguva yekurapwa kweEpclusa is12 vhiki.

Side migumisiro uye njodzi

Harvoni naEpclusa mese mishonga inonzi yakananga-inoshanda antivirals uye ine mhedzisiro yakafanana mumuviri. Nekuda kweizvi, zvinokonzeresa yakawanda yemimwe mhedzisiro. Pazasi pane mimwe mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Zvimwe zvakajairika mhedzisiro mhedzisiro inogona kuitika neese Harvoni naEpclusa anosanganisira:

Yakakomba mhedzisiro

Yakakomba mhedzisiro mhedzisiro inogona kuitika neese Harvoni naEpclusa anosanganisira:

• hepatitis B kumutsidzazve (apo hutachiona hwekare hwunoshanda zvakare), izvo zvinogona kutungamira mukundikana kwechiropa kana kufa (ona "Nyevero dzeBhokisi" pazasi)
• kukanganiswa kwehutachiona, zvine zviratidzo zvinogona kusanganisira kunetseka kufema uye angioedema (kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka)

Nyevero dzebhokisi

Harvoni naEpclusa vese vane yambiro yebhokisi kubva kuDAA. Nyevero yebhokisi ndiyo yambiro yakasimba iyo FDA inoda.

Yambiro inotsanangura njodzi yekuzvimba chiropa hepatitis B mushure mekutanga kurapwa nechero mushonga. Kugadzirisazve hepatitis B kunogona kutungamira kukuvara kwakakomba kwechiropa, kukundikana kwechiropa, kana kufa.

Chiremba wako achakuedza hepatitis B usati watanga kutora Harvoni kana Epclusa. Kana iwe ukaedza kuratidza kuti une hepatitis B, ungangoda kutora mishonga kuti uirape.

Kubudirira

Zvinoenderana nemanyorerwo ekurapa, Harvoni naEpclusa vese vari vaviri vekutanga-kusarudza mishonga yekurapa hepatitis C genotypes 1, 4, 5, uye 6. Mamwe mazano anosanganisira anotevera:

• Harvoni isarudzo yekutanga-sarudzo yekurapa genotypes 1, 4, 5, uye 6 muvana vane makore gumi nemaviri zvichikwira (kana kuyera mapaundi makumi manomwe nemanomwe uye mukuru).
• Epclusa ndiyo yekutanga-sarudzo sarudzo yekurapa genotypes 2 uye 3.

Harvoni naEpclusa vakafananidzwa muzvidzidzo zvekuchipatara. Ose akawanikwa achishanda zvakanyanya pakurapa hepatitis C. Zvisinei, Epclusa inogona kurapa huwandu hwakawanda hwevanhu kupfuura Harvoni.

Mune imwe kiriniki yekuongorora, vanopfuura makumi mapfumbamwe nematatu muzana yevanhu vakagashira ledipasvir uye sofosbuvir, izvo zvikamu zveHarvoni, zvakaporeswa pahepatitis C. Chiyero chekurapa kwevanhu vakagamuchira velpatasvir uye sofosbuvir, izvo zvikamu zveEpclusa, zvaive zvakakura kupfuura 97 muzana.

Chidzidzo chechipiri chakawana mhedzisiro yakafanana kune vanhu vane muripo wechiropa cirrhosis. Chimwe chidzidzo chakawana zvakare kuti Epclusa akarapa hepatitis C muzvikamu zvakakura zvevanhu kupfuura Harvoni.

Mune zvese zvidzidzo zvitatu, iyo SVR yaive yakati kwirei kune Epclusa pane yeHarvoni. SVR inomirira yakasimba virologic mhinduro, zvinoreva kuti hutachiona haugone kuonekwa mumuviri wako.

Mariro

Harvoni naEpclusa vese vari vaviri zita rezita mishonga. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, Harvoni inowanzo kudhura kupfuura Epclusa. Mutengo chaiwo waunobhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa uye chemishonga yaunoshandisa.

Tarira: Generic vhezheni yemishonga iyi miviri inotarisirwa kuburitswa kutanga kwa2019.Mugadziri anofungidzira kuti mutengo wechikamu chemushonga wega wega uchave $ 24,000. Uyu mutengo wakaderera zvishoma kupfuura mutengo weiyo zita-zita vhezheni.

Harvoni vs. Mavyret

Harvoni ine mishonga miviri mupiritsi imwe: ledipasvir uye sofosbuvir. Mavyret zvakare ine mishonga miviri mupiritsi imwe: glecaprevir uye pibrentasvir.

Zvishandiso

Harvoni naMavyret vese vanobvumidzwa neDFA kurapa hepatitis C. Zvisinei, ivo vanoshandiswa kurapa akasiyana genotypes mumamiriro akasiyana.

• Harvoni inobvumidzwa kurapa hepatitis C genotypes 1, 4, 5, uye 6. Mavyret inobvumidzwa kurapa ese matanhatu genotypes makuru.
• Mishonga iyi miviri inoshandiswa kurapa vanhu vakabhadhara cirrhosis. Harvoni inogona zvakare kushandiswa kune vanhu vane decompensated cirrhosis, asi Mavyret haigone.
• Ose ari maviri anogona kushandiswa kune vanhu vakave nechiropa chekuisa.
• Mavyret inogona kushandiswa muvanhu vane chirwere chakakomba cheitsvo kana mushure mekuisirwa itsvo, asi Harvoni haina kubvumidzwa kune izvi zvinoshandiswa.
• Harvoni inobvumidzwa kurapa hepatitis C muvana vane makore gumi nemaviri zvichikwira kana vanorema anosvika makumi manomwe nemaviri mapaundi. Mavyret inogamuchirwa chete kuti ishandiswe muvakuru.
• Yese mishonga inobvumidzwa kurapa vanhu vakaedza imwe hepatitis C mishonga munguva yakapfuura.

Mafomu emishonga uye manejimendi

Harvoni naMavyret vese vanouya semapiritsi aunotora kamwe pazuva. Nekudaro, iwe uchinge uchitora piritsi rimwe reHarvoni pazuva, iwe unotora matatu Mahwendefa pazuva.

Harvoni inogona kutorwa pamwe kana pasina chikafu, asi Mavyret inofanirwa kutorwa pamwe nekudya.

Harvoni inogona kunyorerwa kwemavhiki masere, gumi nemaviri, kana makumi maviri nemana ekurapwa. Nguva yekurapwa kwaMavyret inogona kunge iri masere, gumi nemaviri, kana gumi nematanhatu. Kureba kwekurapwa uko chiremba wako anoraira kunobva pane yako hepatitis C genotype, chiropa mashandiro, uye nhoroondo yeakapfuura hepatitis C.

Side migumisiro uye njodzi

Harvoni naMavyret vane zvakafanana mitezo pamuviri. Izvi zvinoreva kuti ivo vanokonzeresa mhedzisiro yakafanana. Pazasi pane mienzaniso yeimwe yeiyi mhedzisiro.

Zvimwe zvakajairika mhedzisiro

Zvimwe zvakajairika mhedzisiro mhedzisiro inogona kuitika neese Harvoni uye Mavyret anosanganisira:

Yakakomba mhedzisiro

Yakakomba mhedzisiro mhedzisiro inogona kuitika neese Harvoni uye Mavyret anosanganisira:

• hepatitis B kuitazve (kana hutachiona hwekare hwatanga kushanda zvakare), izvo zvinogona kutungamira kukuvara kwakakomba kwechiropa, kukundikana kwechiropa, kana kufa (ona "Nyevero dzeBhokisi" pazasi)
• chirwere chakakomba, uye zviratidzo zvinogona kusanganisira kunetseka kufema uye angioedema (kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka)

Nyevero dzebhokisi

Harvoni naMavyret vese vane mabhokisi akanyeverwa kubva kuDFA. Nyevero yebhokisi ndiyo yambiro yakasimba iyo FDA inoda.

Yambiro inotsanangura njodzi yekuzvimba chiropa hepatitis B mushure mekutanga kurapwa nechero mushonga. Hepatitis B kugadzirisazve kunogona kutungamira kukuvadza kwakakomba kwechiropa, kukundikana kwechiropa, kana kufa.

Chiremba wako achakuedza hepatitis B usati watanga kutora Harvoni kana Mavyret. Kana iwe ukaedza kuratidza kuti une hepatitis B, ungangoda kutora mishonga kuti uirape.

Kubudirira

Harvoni naMavyret havana kuenzaniswa muzvidzidzo zvekuchipatara, asi ese ari maviri anoshanda pakurapa hepatitis C.

Zvinoenderana nemazano ekurapa, Harvoni naMavyret vese vari vaviri-sarudzo dzekutanga dzekurapa hepatitis C genotypes 1, 4, 5, uye 6. Mavyret zvakare isarudzo yekutanga-sarudzo yejenotypes 2 ne3. mamwe mamiriro ekurapa apo mumwe mushonga ungakurudzirwa pamusoro peumwe:

• Vana vane makore gumi nemaviri zvichikwira kana vanorema mapaundi makumi manomwe nemanomwe kana kudarika: Harvoni isarudzo yekutanga-yekurapa vana ava nemagenotypes 1, 4, 5, uye 6. Mavyret haina kukurudzirwa kuti ishandiswe muvana.
• Chirwere chakakomba cheitsvo: Mavyret isarudzo yekutanga-yekurapa hepatitis C kune vanhu vane chirwere ichi. Harvoni haina kukurudzirwa kune vanhu vane chirwere chakakomba cheitsvo.
• Yakagadziriswa cirrhosis: Kune vanhu vane decompensated cirrhosis, Harvoni inokurudzirwa kuti ishandiswe ne ribavirin. Mavyret haina kukurudzirwa kune vanhu vane chirwere ichi.
• Itsvo kuisazve: Kune vanhu vakagamuchira itsvo kuisirwa, ese madhiragi anokurudzirwa seyekutanga-mutsetse sarudzo kune vanhu vane genotypes 1 kana 4. (Harvoni inoshandiswa isiri-label yechinangwa ichi.) , 3, 5, kana 6 vakamboiswa itsvo, asi Harvoni haasi.
• Chiropa chinotamisa: Kurapa kurudziro yekushandiswa kweHarvoni neMavyret kwakasiyana kune vanhu vane chiropa chinotapukira. Izvo zvinoenderana nejenotype uye chiropa chinoshanda.

Mariro

Harvoni naMavyret vese vari vaviri zita rezita mishonga. Ikozvino parizvino hapana generic mafomu eimwe mishonga iripo. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, Harvoni kazhinji inodhura zvakanyanya kupfuura Mavyret. Iko chaiko mutengo waunobhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa uye chemishonga yaunoshandisa.

Tarira: Generic vhezheni yeHarvoni inotarisirwa kuburitswa kutanga kwa2019.Mugadziri anofungidzira mutengo wechikoro chemushonga uchave $ 24,000. Uyu mutengo wakaderera zvishoma kupfuura mutengo weiyo zita-zita vhezheni.

Harvoni vs. Sovaldi

Harvoni naSovaldi ese ari maviri anoshandiswa kurapa hepatitis C. Harvoni ipiritsi rekubatanidza rine mishonga miviri: ledipasvir uye sofosbuvir. Sovaldi ine mumwe mushonga: sofosbuvir.

Zvishandiso

Harvoni FDA-inogamuchirwa kurapa hepatitis C muvanhu vakuru vane genotypes 1, 4, 5, kana 6. Inogona zvakare kushandiswa kurapa vana vane aya genotypes vane makore gumi nemaviri zvichikwira kana vanorema anosvika makumi manomwe nemaviri mapaundi.

Sovaldi inobvumidzwawo kurapa hepatitis C, asi inoshandiswa muvakuru vane genotypes 1, 2, 3, kana 4. Inogona zvakare kushandiswa muvana vane genotypes 2 kana 3 vane makore gumi nemaviri kana kupfuura kana vanorema mapaundi makumi manomwe kana kupfuura .

Sovaldi inoshandiswa pamwe chete nemimwe mishonga yekurapa hepatitis C. Haisi FDA-inogamuchirwa kuti ishandiswe yega.

Mafomu emishonga uye manejimendi

Harvoni naSovaldi vese vanouya semapiritsi aunotora nemuromo. Harvoni inotorwa kamwe chete zuva rega rega kwemavhiki masere, gumi nemaviri, kana makumi maviri nemana. Sovaldi inotorwawo kamwe chete zuva nezuva, asi kwevhiki gumi nembiri kana makumi maviri nemana.

Mishonga yese iyi ine sofosbuvir, asi Harvoni musanganiswa wemishonga inogona kushandiswa pachayo kune vamwe vanhu. Sovaldi haina kushandiswa pachayo kurapa hepatitis C. Inotemerwa nemimwe mishonga, inosanganisira pegylated interferon uye ribavirin (Rebetol). Iyo generic fomu yeSovaldi inowanikwawo mune mamwe musanganiswa hepatitis C mishonga.

Side migumisiro uye njodzi

Yese mishonga ine sofosbuvir, saka inokonzeresa yakawanda yakafanana mhedzisiro. Zvisinei, Sovaldi anogara achitorwa akabatana nemimwe mishonga, iyo inogona kushanda zvakasiyana kubva kuHarvoni. Nekuda kweizvi, mhedzisiro inoonekwa pamwe neSovaldi kurapwa kunoenderana nemushonga wainoshandiswa nawo.

Zvakajairika uye zvakakomba mhedzisiro yeHarvoni naSovaldi zvinoratidzwa pazasi. Iyo Sovaldi mhedzisiro inotsanangurwa inoonekwa apo Sovaldi inoshandiswa nehumwe hepatitis C mishonga senge ribavirin uye pegylated interferon.

Harvoni naSovaldi vese vane yambiro yebhokisi kubva kuDFA ye hepatitis B kugadzirisazve. Nyevero yebhokisi ndiyo yambiro yakasimba iyo FDA inoda. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Kubudirira

Harvoni naSovaldi vane zvakasiyana zvakasiyana-siyana zvinoshandiswa neDFA, asi zvose zviri zviviri zvinoshandiswa kurapa hepatitis C. Harvoni inoshanda kurwisa hutachiona painoshandiswa yoga kana ne ribavirin. Sovaldi inoshanda pakurapa hepatitis C chete kana ikashandiswa pamwe chete nemimwe mishonga, senge ribavirin uye pegylated interferon.

Zvinoenderana nemazano ekurapa, Harvoni ndiyo yekutanga-sarudzo yekurapa hepatitis C muvanhu vane genotypes 1, 4, 5, kana 6. Ichowo chisarudzo chekutanga-sarudzo muvana vane makore gumi nemaviri zvichikwira kana vanorema angangoita makumi manomwe nemaviri mapaundi.

Sovaldi haichakurudzirwi nemirayiridzo yekurapa senzira yekutanga-sarudzo yekurapa hepatitis C. Izvi zvinodaro nekuti mishonga mitsva yakadai saHarvoni inoonekwa seinoshanda. Mishonga mitsva zvakare inokonzeresa mashoma mhedzisiro.

Nekudaro, Sovaldi dzimwe nguva anokurudzirwa seyechipiri-sarudzo yekurapa kune vamwe vanhu, asi inofanirwa kushandiswa musanganiswa nemimwe mishonga.

Mariro

Harvoni naSovaldi mazita ezita remishonga. Ikozvino hapana mafomu akajairika anowanikwa chero emushonga.

Zvinoenderana nekufungidzira paGoodRx.com, Harvoni kazhinji inodhura zvishoma kupfuura Sovaldi. Mutengo chaiwo waunobhadhara chero mushonga unobva pane yako inishuwarenzi uye pharmacy yaunoshandisa.

Tarira: Generic vhezheni yeHarvoni inotarisirwa kuburitswa kutanga kwa2019.Mugadziri anofungidzira mutengo wechikoro chemushonga uchave $ 24,000. Uyu mutengo wakaderera zvishoma kupfuura mutengo weiyo zita-zita vhezheni.

Harvoni vs. Zepatier

Harvoni ine mishonga ledipasvir uye sofosbuvir mupiritsi imwe. Zepatier zvakare ine mishonga miviri mupiritsi imwe: elbasvir uye grazoprevir.

Zvishandiso

Harvoni naZepatier vari vaviri FDA-inogamuchirwa kurapa hepatitis C hutachiona muvakuru vane genotypes 1 kana 4. Harvoni inobvumidzwawo kurapa genotypes 5 ne6 muvakuru, uye genotypes 1, 4, 5, kana 6 muvana vane makore gumi nemaviri kana kupfuura. kana uyo anorema angangoita mazana manomwe emapaundi. Zepatier haina kubvumidzwa kushandiswa muvana.

Harvoni inobvumidzwa kurapa hepatitis C hutachiona muvakuru vane decompensated cirrhosis kana ndiani ave nechiropa chekuisa. Nemamiriro aya, chiremba wako anogona kunyorera ribavirin naHarvoni.

Zepatier haina kubvumidzwa kuti ishandiswe muvanhu vane chirwere chine mwero kana chakakomba chechiropa, yakaora cirrhosis, kana mushure mekuisirwa chiropa.

Zepatier FDA-inogamuchirwa kuti ishandiswe mune vanhu vane genotypes 1 ne4 vane mamiriro anonzi polymorphism. Nemamiriro aya, munhu ane mamwe majenasi akasiyana (magene) anoita kuti hutachiona husabatike nemimwe mishonga. Kana hutachiona husingabatike, zvinonetsa kurapa nemimwe mishonga.

Chiremba wako achaita ongororo yeropa kuti aone kana iwe uine imwe yemisiyano iyi. Kana ukadaro, ungangoda kutora ribavirin naZepatier.

Mafomu emishonga uye manejimendi

Harvoni naZepatier vese vanouya sehwendefa rimwe chete rinotorwa kamwe chete zuva nezuva. Imwe neimwe inogona kutorwa pamwe kana pasina chikafu.

Kurapa kweHarvoni kunotora kwemavhiki masere, gumi nemaviri, kana makumi maviri nemana. Zepatier kurapwa kunotora kwemavhiki gumi nemaviri kana gumi nematanhatu. Iyo nguva yekurapa yaunorayirwa nachiremba yako ichave yakavakirwa pane yako genotype, chiropa mashandiro, uye nhoroondo yezvakaitika hepatitis C kurapwa.

Side migumisiro uye njodzi

Harvoni naZepatier mishonga yakafanana uye mhedzisiro yavo pamuviri yakafanana. Naizvozvo, zvinokonzeresa yakawanda yemimwe mhedzisiro. Pazasi pane mimwe mienzaniso yemhedzisiro yavo.

Harvoni naZepatier vese vane yambiro yebhokisi kubva kuDFA ye hepatitis B kugadzirisazve. Nyevero yebhokisi ndiyo yambiro yakasimba iyo FDA inoda. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Kubudirira

Harvoni naZepatier havana kuenzaniswa muzvidzidzo zvekuchipatara, asi ese ari maviri anoshanda pakurapa hepatitis C.

Zvinoenderana nemazano ekurapa, ese ari maviri Harvoni naZepatier vanokurudzirwa senzira dzekutanga kurapa hepatitis C muvanhu vakuru vane genotypes 1 ne4. Harvoni zvakare sarudzo yekutanga-yekurapa genotypes 5 ne6, asi Zepatier haasi.

Nhungamiro kurudziro yeHarvoni naZepatier zvakare inosiyana mune inotevera mamiriro:

• Vana vane makore gumi nemaviri zvichikwira kana vanorema mapaundi makumi manomwe nemanomwe kana kudarika: Harvoni ndiyo yekutanga-sarudzo yekurapa vana ava vane genotypes 1, 4, 5, uye 6. Zepatier haina kukurudzirwa kuti ishandiswe muvana.
• Chirwere chakakomba cheitsvo: Zepatier inokurudzirwa senzira yekutanga-sarudzo kune vanhu vane mamiriro aya, nepo Harvoni asiri.
• Yakagadziriswa cirrhosis: Mune vanhu vane decompensated cirrhosis, Harvoni inokurudzirwa senzira yekutanga-sarudzo. Zepatier haina kukurudzirwa kune vanhu vane chirwere ichi.
• Chiropa kana itsvo kuisazve: Harvoni isarudzo yekutanga-sarudzo yekurapa hepatitis C muvanhu vakave nechiropa kana itsvo kuisirwa. Zepatier haina kukurudzirwa kune vanhu vane aya mamiriro.

Mariro

Harvoni naZepatier mishonga yemazita ezita. Ikozvino hapana mafomu akajairika anowanikwa chero mushonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, Harvoni kazhinji inodhura zvakanyanya kupfuura Zepatier. Iko chaiko mutengo waunobhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa uye chemishonga yaunoshandisa.

Tarira: Generic vhezheni yeHarvoni inotarisirwa kuburitswa kutanga kwa2019.Mugadziri anofungidzira mutengo wechikoro chemushonga uchave $ 24,000. Uyu mutengo wakaderera zvishoma kupfuura mutengo weiyo zita-zita vhezheni.

Maitiro ekutora Harvoni

Iwe unofanirwa kutora Harvoni zvinoenderana nemirairo yechiremba wako.

Nguva

Harvoni inogona kutorwa chero nguva yezuva. Nekudaro, iwe unofanirwa kuedza kutora Harvoni panguva imwechete mazuva ese. Izvi zvinogona kukubatsira kuyeuka kuitora uye kubatsira kuchengetedza yakaenzana huwandu hwechirwere mune yako system.

Kana iwe uchinzwa kuneta panguva yekurapa kwako naHarvoni, edza kutora mushonga usiku. Izvo zvinogona kukubatsira iwe kunzvenga iro divi mhedzisiro.

Kutora Harvoni nechikafu

Harvoni inogona kutorwa pamwe kana pasina chikafu. Kana iwe uchinge uchinge wasvotwa mushure mekutora Harvoni, unogona kudzivirira iro divi mhedzisiro nekutora mushonga nechikafu.

Inogona Harvoni kupwanywa here?

Hazvizivikanwe kana zvakachengeteka kupwanya mapiritsi eHarvoni, saka zviri nani kuti usaapwanya. Kana uchinetseka kumedza mapiritsi eHarvoni, taura nachiremba wako nezvemimwe mishonga inogona kukuitira zvirinani.

Mashandiro anoita Harvoni

Harvoni inoshandiswa kurapa hutachiona nehutachiona hwehepatitis C (HCV).

Nezve hepatitis C

HCV inopfuudzwa kuburikidza neropa kana mvura yemumuviri. Utachiona hunonyanya kurwisa masero muchiropa chako uye chinokonzera kuzvimba. Izvi zvinotungamira kuzviratidzo zvakaita se:

• kurwadziwa mudumbu rako (dumbu)
• kupindwa nechando
• weti yakasviba
• kurwadza kwemajoini
• jaundice (yero yeganda rako kana machena emaziso ako)

Dzimwe immune system dzevanhu dzinogona kurwisa HCV pasina kurapwa. Zvisinei, vanhu vazhinji vanoda mishonga yekujekesa hutachiona uye kuderedza kwenguva yakareba migumisiro. Yakakomba, yakareba-mhedzisiro mhedzisiro yehepatitis C inosanganisira cirrhosis (chironda chekushaiwa) uye kenza yechiropa.

Harvoni anorapa sei hepatitis C?

Harvoni ndeye yakananga-inoshanda antiviral (DAA). Aya marudzi emishonga anorapa HCV nekumisa hutachiona kubva pakuberekana (kugadzira makopi acho pachawo). Mavhairasi asingagone kuita makopi anopedzisira afa uye anojekeswa kubva mumuviri.

Kuchenesa hutachiona kubva mumuviri wako kunoderedza kuzvimba kwechiropa uye kudzivirira kuwedzerwa kwechiropa.

Zvinotora nguva yakareba sei kuti zvishande?

Vamwe vanhu vanotanga kunzwa zvirinani mukati memazuva mashoma kana mavhiki ekutanga kurapwa naHarvoni. Zvisinei, iwe unenge uchiri kuda kutora Harvoni kwenguva yose iyo inorairwa nachiremba wako.

Muzvidzidzo zvemakiriniki, vanopfuura makumi mapfumbamwe neshanu muzana yevanhu vakatora Harvoni vakaporeswa mushure memwedzi mitatu yekurapwa.

Chiremba wako anozoongorora ropa rako kuti utachiona here uye usati warapwa. Vanozozviedzawo vhiki gumi nemaviri mushure mekupedza kurapwa. Kana pasina hutachiona hunoonekwa mumuviri wako masvondo gumi nemaviri mushure mekunge kurapwa kwako kwapera, iwe wawana yakasimba ye virologic mhinduro (SVR). Kuzadzikisa SVR zvinoreva kuti unofungidzirwa kuti wakaporeswa pahepatitis C.

Harvoni uye nhumbu

Iko hakuna kuve nezvakakwana zvidzidzo muvanhu kuziva kana Harvoni yakachengeteka kutora panguva yekuzvitakura. Mune zvidzidzo zvemhuka, pakanga pasina chakaipa kumucheche akaonekwa apo amai vakagamuchira Harvoni. Zvisinei, zvidzidzo zvemhuka hazviwanzo kufanotaura zvichaitika muvanhu.

Kana iwe uine pamuviri kana kuronga kuva nepamuviri, taura nachiremba wako nezvekuti Harvoni akakukodzera here.

Ongorora: Kana iwe uri kutora Harvoni ine ribavirin, iyo kurapwa haina kuchengetedzeka kushandisa panguva yekuzvitakura (ona "Harvoni uye ribavirin" pamusoro).

Harvoni nekuyamwisa

Hazvizivikanwe kana Harvoni achipfuura mumukaka wemukaka wemunhu. Muzvidzidzo zvemhuka, Harvoni akawanikwa mumukaka wemukaka asi haana kukonzera zvinokuvadza mumwana. Zvisinei, zvidzidzo zvemhuka hazviwanzo kufanotaura zvichaitika muvanhu.

Kana iwe uchiyamwisa kana kuronga kuyamwisa, taura nachiremba wako nezve zvingangoitika njodzi uye zvakanakira kutora Harvoni uchiri kuyamwa.

Tarira: Kana iwe uri kutora Harvoni ne ribavirin, iwe unofanirwa kutaura nachiremba wako nezvekuti iwe unogona kuramba uchiyamwisa zvakachengeteka (ona "Harvoni uye ribavirin" pamusoro).

Mibvunzo yakajairika nezveHarvoni

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Harvoni.

Ini ndinofanira here kutevera yakakosha kudya ndichitora Harvoni?

Kwete, hapana chakakosha chikafu chinodiwa paunenge uchitora Harvoni.

Zvisinei, kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge Kutora Harvoni nechingwa chidiki kunogona zvakare kudzikisira kushungurudzika.

Inguva yakareba sei Harvoni achatora kubvisa hepatitis C yangu?

Harvoni ichatanga kushanda ipapo ipapo kurwisa hutachiona. Nekudaro, kuti ubvise hepatitis C, iwe unofanirwa kutora Harvoni kwenguva izere yenguva yakarairwa nachiremba wako. Aya anogona kunge ari masvondo masere, gumi nemaviri, kana makumi maviri nemana, zvinoenderana nezvenhoroondo yako yekurapa.

Muzvidzidzo zvemakiriniki, vangangoita vanhu vese vakatora Harvoni vakawana yakasimba virologic mhinduro SVR) mushure mekurapwa kwakazara. SVR zvinoreva kuti hutachiona hwakange husisaoneke muropa ravo. Kana munhu awana SVR, vanoonekwa sevanorapwa hepatitis C.

Ndeupi mushonga weHarvoni?

Kurapa kweHarvoni kunoenderana nehumwe hutachiona hwehepatitis C. Izvi zvinosanganisira kana kuti hauna cirrhosis, ndeapi hepatitis C marapirwo awakaedza munguva yakapfuura, uye rudzii rwehutachiona hwauinaro.

Semuenzaniso, muzvidzidzo zvekuchipatara zveHarvoni, 96 muzana yevanhu vakasangana nerondedzero inotevera vakaporeswa hepatitis C mushure memavhiki gumi nemaviri:

• yakanga iine genotype 1
• anga asina chirwere checirrhosis
• yakanga isina nhoroondo yehumwe hepatitis C kurapwa

Muzvidzidzo zvakafanana zvekiriniki, pakati pe86 muzana uye zana muzana yevanhu vane nhoroondo dzakasiyana dzekurapa vakaporeswa hepatitis C.

Ko hepatitis C inogona kudzoka mushure mekutora Harvoni?

Kana iwe ukatora Harvoni mazuva ese sekurairwa nachiremba wako uye iwe uchichengetedza mararamiro ane hutano, hutachiona haufanire kudzoka.

Zvisinei, zvinokwanisika kudzokazve (utachiona huonekwazve). Izvi zvinoitika kana mushonga warapa munhu wehepatitis C, asi kuongororwa kweropa kunoona hutachiona zvakare mwedzi kana makore mushure mekurapwa. Mumakiriniki miedzo, kusvika pa6 muzana yevanhu vakabatwa naHarvoni vakatangazve.

Zvakare, kana iwe ukaziviswa kune hepatitis C zvakare mushure mekutora chero hepatitis C mishonga, kusanganisira Harvoni, unogona kutapukirwa nehutachiona. Reinfection inogona kuitika nenzira imwecheteyo hutachiona hwepakutanga hwakabatwa.

Kugovera tsono dzinoshandiswa kubaya jekiseni zvinodhaka uye kusangana pabonde pasina kondomu ingangoita nzira dzekudzorerwazve. Kudzivisa maitiro aya kunogona kubatsira kudzivirira kutapukirazve nehepatitis C.

Chii chinonzi hepatitis C genotype?

Kune hutanhatu hutanhatu, kana mhando, dzehutachiona hwehepatitis C dzinozivikanwa kutapurira vanhu. Aya madhiraini anonzi genotypes.

Magenotypes anoonekwa nemisiyano iri mugeneti kodhi yemavhairasi. Iyo inonyanya kuzivikanwa hepatitis C strain muUnited States ndeye genotype 1, asi mamwe maratidziro anoonekwawo pano.

Chiremba wako anokupa ongororo yeropa kuti uone kuti une genotype ipi. Yako hepatitis C genotype inobatsira chiremba wako kusarudza kuti ndeupi mushonga wakakukodzera.

Harvoni kudarika

Kana iwe ukatora zvakawandisa Harvoni, iwe unowedzera njodzi yako yemhedzisiro mhedzisiro.

Ovhadhozi zviratidzo

Zviratidzo zvekuwedzeredza kweHarvoni zvinogona kusanganisira:

• kuneta
• kurwadziwa nemusoro zvakanyanya
• kusvotwa uye kurutsa
• kushaya simba kwetsandanyama
• kushaya hope (kunetseka kurara)
• kugumbuka

Zvekuita kana ovhadhozi

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako kana kutsvaga nhungamiro kubva kuAmerican Association of Poison Control Centers pa800-222-1222 kana kuburikidza nechavo online chishandiso Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Harvoni yambiro

Mushonga uyu unouya neyambiro zhinji.

FDA yambiro: Kugadzirisazve hutachiona hwehepatitis B

Mushonga uyu une yambiro yebhokisi. Iyi ndiyo yambiro yakanyanya kubva kuFood and Drug Administration (FDA). Yambiro yebhokisi inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

• Kana vanhu vakabatwa nezvose zviri zviviri hepatitis C uye hepatitis B vatanga kutora Harvoni, pane mukana wekumutsazve hutachiona hwehepatitis B (HBV). Kubata zvakare kunoreva kuti hutachiona hunotanga kushanda zvakare. Kugadziriswa kweHBV kunogona kutungamira kukundikana kwechiropa kana kufa. Chiremba wako achakuedza kuti uone HBV usati watanga kurapwa naHarvoni. Kana iwe ukawanikwa uine HBV, ungangoda kutora mishonga kuti uirape.

Dzimwe yambiro

Usati watora Harvoni, taura nachiremba wako nezve nhoroondo yako yehutano. Harvoni inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo.

Hazvizivikanwe kana Harvoni yakachengeteka kana inoshanda muvanhu vane chirwere chakakomba cheitsvo. Izvi zvinosanganisira vanhu vane kukanganiswa kwakanyanya kweitsvo kana vane chirwere cheitsvo chekupedzisira chinoda hemodialysis. Nekudaro, vanhu vane chirwere chakakomba cheitsvo avo vakatora Harvoni muchidzidzo chekiriniki cha2018 vakarapwa mushe uye havana kukuvara zvakanyanya.

Kana iwe uine chirwere chakakomba cheitsvo, taura nachiremba wako nezvekuti Harvoni akakukodzera here.

Harvoni kupera

Kana Harvoni ichiburitswa kubva kukhemisi, wemishonga anowedzera zuva rekupera kune zvakanyorwa pabhodhoro. Zuva iri rinowanzo kuve gore rimwe kubva musi wakapihwa mushonga.

Chinangwa chemazuva ekupera akadaro ndechekuvimbisa kushanda kwemushonga panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga.

Inguva yakareba sei mushonga unoramba wakanaka unogona kubva pane zvakawanda zvinhu, zvinosanganisira kuti uye kupi mushonga unochengeterwa. Mahwendefa eHarvoni anofanirwa kuchengetwa pazasi pe86⁰F (30⁰C) uye agochengetwa mumudziyo wavakauya nawo.

Kana iwe usina kushandisa mishonga iyo yapfuura nguva yayo yekupera, taura nachiremba wako nezvekuti iwe uchiri kukwanisa kuishandisa here.

Ruzivo rwehunyanzvi rweHarvoni

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Nzira yekuita

Harvoni ine mishonga miviri: ledipasvir uye sofosbuvir.

Ledipasvir inhibits HCV NS5A protein, iyo inodiwa kuti phosphorylation inoshanda yehutachiona RNA. Kuvhiringidzwa kwe NS5A kunovhara RNA kudzokororwa uye kuungana.

Sofosbuvir inonzi HCV NS5B polymerase inhibitor ine metabolite inoshanda (nucleoside analog triphosphate) inosanganisirwa muHCV RNA. Iyo inoshanda yemetabolite inoshanda seketani terminator, ichimisa kudzokorora kweHCV.

Harvoni ine zviitiko zvinopesana neHCV genotypes 1, 4, 5, uye 6.

Pharmacokinetics uye metabolism

Harvoni ine zvinhu zviviri zvinoshanda: ledipasvir uye sofosbuvir.

Ledipasvir inosvika pakakwirira pehusungwa mumaawa angangoita mana uye inenge yakasungwa zvakakwana kumapuroteni eplasma. Metabolism inoitika kuburikidza neiyo oxidation kuburikidza nenzira isingazivikanwe. Hafu yeupenyu inenge maawa makumi mana nemanomwe. Iyo isina kuchinjika mushonga uye ayo oxidative metabolites anobviswa kunyanya mutsvina yadzo.

Sofosbuvir's peak concentration inoitika mumaminitsi makumi mana nemashanu kusvika paawa rimwe. Plasma protein inosunga maakaundi angangoita makumi matanhatu neshanu muzana ezvekutenderera zvinodhaka. Sofosbuvir mushonga unoshandurwa kuita metabolite inoshanda (GS-461203) nehydrolysis uye phosphorylation muchiropa. GS-461203 inoenderera mberi dephosphorylated kune isingashande metabolite.

Kusvika pamakumi masere muzana muzana yemutero unobviswa mumuti weti. Hupenyu hwemubereki hune hafu yeupenyu maminetsi makumi matatu, uye hafu-yehupenyu husina simba iri maawa makumi maviri nemanomwe.

Contraindications

Iko hakuna zvinopesana neHarvoni kushandiswa. Tarisa kune ribavirin ichipa ruzivo rwekupokana kwevanhu vanogamuchira Harvoni ne ribavirin.

Kuchengetedza

Harvoni inofanirwa kuchengetwa mumudziyo wayo wepakutanga pane tembiricha yakaderera pane 86⁰F (30⁰C).

Disiki: MedicalNewsToday yaedza nepese painogona kuti ive nechokwadi chekuti ruzivo rwese nderwechokwadi, rwakakwana, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.