HER2-Yakanaka Breast Cancer Kupona Mitengo uye Dzimwe Statistics

Zvemukati

• Ndeapi matanho ekupona?
• Chii chiri kuwanda kweHER2-yakanaka kenza yemazamu?
• Inogona here HER2-yakanaka kenza yemazamu kudzoka?
• Ndeapi marapirwo aripo?
• Kuvhiya
• Radiation
• Chemotherapy
• Targeted kurapwa
• Trastuzumab (Herceptin)
• Ado-trastuzumab emtansine (Kadcyla)
• Neratinib (Nerlynx)
• Pertuzumab (Perjeta)
• Lapatinib (Tykerb)
• Ndeapi maonero?

Chii chinonzi HER2-positive kenza yemazamu?

Gomarara repazamu hachisi chirwere chimwe. Chaizvoizvo boka rezvirwere. Paunenge uchiongorora kenza yemazamu, rimwe rematanho ekutanga kuratidza kuti une rudzii. Rudzi rwegomarara repazamu runopa ruzivo rwakakosha nezve maitiro egomarara.

Paunenge uine chipfuva chechipfuva, iwo maturu anoedzwa mahormone receptors (HR). Izvo zvakare zvakaedzwa kune chimwe chinonzi munhu epidermal kukura factor receptor 2 (HER2). Mumwe nemumwe anogona kuve nechekuita mukuvandudzwa kwekenza yemazamu.

Mune mimwe mishumo yezvirwere, HER2 inonzi HER2 / neu kana ERBB2 (Erb-B2 receptor tyrosine kinase 2). Mahormone receptors anoonekwa seestrogen (ER) uye progesterone (PR).

Iyo HER2 geni inogadzira HER2 mapuroteni, kana ma receptors. Izvi zvinogamuchira zvinobatsira kudzora kukura uye kugadzirisa kwemazamu maseru. Kuwedzeredza kweHER2 protein kunokonzera kunze-kweku-kudzora kubereka kwemasero emazamu.

HER2-yakanaka kenza yemazamu inowanzo kuve ine hukasha kupfuura HER2-isina kenza yemazamu. Pamwe pamwe nebundu giredhi nekenza nhanho, HR uye HER2 chinzvimbo chinobatsira kuona maitiro ekurapa.

Enderera kuverenga kuti udzidze zvakawanda nezve HER2-yakanaka kenza yemazamu uye zvaunogona kutarisira.

Ndeapi matanho ekupona?

Panguva ino, hakuna kumbove nekutsvagisa kwakanangana nezvekupona kwehutachiwana hweHER2-positive kenza yemazamu chete. Ongororo dzazvino nezve kenza yemazamu yekupona mitengo inoshanda kune ese marudzi.

Zvinoenderana neNational Cancer Institute (NCI), aya ndiwo makore mashanu ekupona kwevakadzi vanoonekwa pakati pa2009 na2015:

• nzvimbo: 98.8 muzana
• dunhu: 85.5 muzana
• kure (kana metastatic): 27.4 muzana
• matanho ese akasanganiswa: 89.9 muzana

Izvo zvakakosha kuti urangarire kuti idzi dzinongova huwandu hwakazara. Yenguva refu-yehupenyu manhamba akavakirwa pane vanhu vakawanikwa makore apfuura, asi kurapwa kuri kuchinja nekukurumidza kumhanya.

Paunenge uchitarisa maonero ako, chiremba wako anofanira kuongorora zvinhu zvakawanda. Pakati pavo pane:

• Nhanho pakuongororwa: Maonero acho ari nani kana gomarara repazamu risina kupararira kunze kwezamu kana rapararira munharaunda chete pakutanga kwekurapwa. Metastatic kenza yemazamu, inova kenza yakapararira kunzvimbo dziri kure, inonetsa kurapa.
• Kukura uye chiyero chepamuviri bundu: Izvi zvinoratidza kuti kenza ine hukasha zvakadii.
• Lymph node kubatanidzwa: Kenza inogona kutapukira kubva kuma lymph node kuenda kune nhengo dziri kure uye nyama.
• HR uye HER2 chinzvimbo: Mishonga yakanangwa inogona kushandiswa kune HR-yakanaka uye HER2-yakanaka kenza yemazamu.
• Utano hwakazara: Dzimwe nyaya dzehutano dzinogona kuomesa kurapwa.
• Mhinduro kurapi: Zvakaoma kufanotaura kana imwe nzira yekurapa ichizoshanda kana kuburitsa isingagone mhedzisiro.
• Zera: Vakadzi vadiki uye avo vanopfuura makore makumi matanhatu vanowanzove nemaonero akaipisisa kupfuura vakadzi vane zera repakati, kusara kweavo vane danho rechitatu gomarara repazamu.

MuUnited States, zvinofungidzirwa kuti vakadzi vanopfuura makumi mana nezviuru vachafa nekenza yemazamu muna 2019.

Chii chiri kuwanda kweHER2-yakanaka kenza yemazamu?

Vanenge gumi nevaviri muzana yevakadzi muUnited States vanozoita kenza yemazamu inoparadza pane imwe nguva. Chero ani, kunyangwe varume, anogona kukura HER2-yakanaka kenza yemazamu. Zvisinei, zvinonyanya kukanganisa vakadzi vaduku. Inenge makumi maviri neshanu muzana emakondera ese emuzamu ane HER2-yakanaka.

Inogona here HER2-yakanaka kenza yemazamu kudzoka?

HER2-yakanaka kenza yemazamu ine hukasha uye inowanzo kudzoka pane HER2-isina kenza yemazamu. Kudzokorora kunogona kuitika chero nguva, asi kunowanzoitika mukati memakore mashanu ekurapwa.

Nhau dzakanaka ndedzekuti kudzokorora kushoma kushoma nhasi kupfuura nakare kose. Izvi zvinonyanya kukonzerwa neazvino marapirwo akanangwa. Muchokwadi, vanhu vazhinji vanorapwa kwekutanga nhanho HER2-yakanaka kenza yemazamu haidzokere shure.

Kana kenza yako yemazamu iri zvakare HR-yakanaka, kurapwa kwehomoni kunogona kubatsira kudzikisa njodzi yekudzokazve.

Chimiro cheHR uye chinzvimbo cheHER2 chinogona kuchinja. Kana kenza yemazamu ikadzokazve, bundu idzva rinofanira kuongororwa kuitira kuti kurapwa kunogona kuongororwa zvakare.

Ndeapi marapirwo aripo?

Urongwa hwako hwekurapa hunogona kusanganisira musanganiswa wemishonga yakadai se:

• kuvhiya
• radiation
• chemotherapy
• zvakanangwa kurapwa

Hormone mishonga inogona kunge iri sarudzo kune vanhu vane gomarara iri zvakare HR yakanaka.

Kuvhiya

Kukura, nzvimbo, uye huwandu hwemamota zvinobatsira kuona kudiwa kwekuvhiya-kuchengetedza zamu kana mastectomy, uye kana kubvisa ma lymph node.

Radiation

Radiation kurapwa inogona kunongedza chero kenza maseru ayo anogona kusara mushure mekuvhiyiwa. Inogona zvakare kushandiswa kudzora mamota.

Chemotherapy

Chemotherapy inzira yekurapa. Mishonga ine simba inogona kutsvaga nekuparadza cancer maseru chero kupi mumuviri. HER2-yakanaka kenza yemazamu inowanzo pindura mushe kune chemotherapy.

Targeted kurapwa

Zvinotarisirwa kurapwa kweHER2-yakanaka kenza yemazamu inosanganisira:

Trastuzumab (Herceptin)

Trastuzumab inobatsira inovhara maseru emukenza kubva mukugamuchira makemikari anokurudzira kukura.

Chidzidzo chegore ra2014 chevakadzi vanopfuura zviuru zvina chakaratidza kuti trastuzumab yakadzora kudzokorodza uye kuvandudzwa kwekupona painowedzerwa kune chemotherapy mune yekutanga nhanho HER2-yakanaka kenza yemazamu Iyo chemotherapy regimen yaive paclitaxel mushure me doxorubicin uye cyclophosphamide.

Iyo yegumi-gore-yekupona mwero yakawedzera kubva pa75.2 muzana ne chemotherapy chete kune 84 muzana pamwe nekuwedzera kwetrastuzumab. Mitengo yekupona pasina kudzokororazve yakaenderera mberi nekuvandudza. Iyo yegumi-gore-chirwere-chisina kupona mwero yakawedzera kubva pa62.2 muzana kusvika 73.7 muzana.

Ado-trastuzumab emtansine (Kadcyla)

Mushonga uyu unobatanidza trastuzumab ne chemotherapy mushonga unonzi emtansine. Trastuzumab inonunura emtansine yakanangana neiyo HER2-yakanaka maseru emukenza. Inogona kushandiswa kudzikira mamota uye kuwedzera kupona mune vakadzi vane metastatic kenza yemazamu.

Neratinib (Nerlynx)

Neratinib kurapwa kwegore-iro rinoshandiswa mumatanho ekutanga eHER2-positive kenza yemazamu. Inopihwa kune vanhu vakuru vakatopedza regimen yekurapa inosanganisira trastuzumab. Chinangwa cheneratinib ndechekuderedza mukana wekudzokazve.

Marapirwo akanangwa anowanzo shanda kubva kunze kwesero kuvharira mamaki emakemikari anokurudzira kukura kwechirwere. Neratinib, kune rumwe rutivi, inokanganisa zviratidzo zvemakemikari kubva mukati memusero.

Pertuzumab (Perjeta)

Pertuzumab mushonga unoshanda zvakanyanya senge trastuzumab. Nekudaro, iyo inonamira kune chakasiyana chikamu cheiyo HER2 protein.

Lapatinib (Tykerb)

Lapatinib inovhara mapuroteni anokonzera kusadzora kukura kwesero. Inogona kubatsira kunonoka kufambira mberi kwechirwere kana metastatic kenza yemazamu ikava isingagone ku trastuzumab.

Ndeapi maonero?

Maererano nekufungidzira, vakadzi vanopfuura mamirioni 3,1 muUnited States vane nhoroondo yekenza yemazamu.

Maonero ekenza yezamu yeHER2-inosiyana kubva pamunhu kuenda kumunhu. Kufambira mberi mune zvakanangwa kurapwa kunoenderera nekuvandudza maonero eese ekutanga nhanho uye metastatic chirwere.

Kamwe kurapwa kwekenza yemazamu isina kupera kunopera, iwe unenge uchiri kuda kuongororwa kwenguva nenguva kuitira zviratidzo zvekudzokazve. Mazhinji mhedzisiro yemhedzisiro yekurapa ichavandudza nekufamba kwenguva, asi mamwe (senge nyaya dzekubereka) anogona kuve anogara nekusingaperi.

Metastatic kenza yemazamu haifungidzirwe kuti inorapwa. Kurapa kunogona kuenderera sekureba kuri kushanda. Kana imwe nzira yekurapa ikamira kushanda, unogona kuchinjira kune imwe.