Izvo Zvese Munhu ane Psoriasis Anofanirwa Kuziva Nezve PDE4 Inhibitors

Zvemukati

• Mhedziso
• Chii chinonzi PDE4 inhibitors?
• Vanoshandira sei psoriasis?
• PDE4 inhibitor kurapa vs. mamwe ma psoriasis ekurapa
• Zvinogona kubatsirwa
• Side migumisiro uye yambiro
• Kutora

Mhedziso

Plaque psoriasis inogara isingaite autoimmune mamiriro. Kureva, immune system inokanganisa kurwisa muviri. Inokonzera matsvuku, makanda makanda kuti akure paganda. Aya mavara anogona dzimwe nguva kunzwa akanyanya kana kurwadza.

Kurapa sarudzo kunovavarira kudzikisa izvi zviratidzo. Nekuti kuzvimba kuri pamudzi wedombo psoriasis, chinangwa chemishonga yakawanda kudzora iyi immune system mhinduro uye kugadzira yakajairika chiyero.

Kana iwe uri kurarama zvine mwero kusvika kune yakaoma plaque psoriasis, PDE4 inhibitor inogona kuve chishandiso chinoshanda mukugadzirisa zviratidzo.

Zvisinei, mishonga haisi yevanhu vose. Iwe unofanirwa kukurukura zvaunogona kurapwa nachiremba wako.

Chii chinonzi PDE4 inhibitors?

PDE4 inhibitors iri kurapwa kutsva. Vanoshanda kudzvinyirira immune system, iyo inoderedza kuzvimba. Ivo vanoita padanho remaseru kumisa kugadzirwa kweiyo enzyme yakanyanyisa inonzi PDE4.

Vatsvagiri vanoziva kuti phosphodiesterases (PDEs) inoshatisa cyclic adenosine monophosphate (cAMP). cAMP inobatsira zvakanyanya kusaina nzira pakati pemasero.

Nekumisa PDE4s, cAMP inowedzera.

Zvinoenderana neongororo ya2016, iyi yakakwira mwero weCAMP inogona kuve neanorwisa-kupisa mhedzisiro, kunyanya kune vanhu vanorarama ne psoriasis uye atopic dermatitis.

Vanoshandira sei psoriasis?

PDE4 inhibitors, senge apremilast (Otezla), inoshanda mukati memuviri kudzivirira kuzvimba.

Seyero yekudzivirira, zvinogona kubatsira kune vanhu vane psoriasis kubata kuzvimba. Kuderedza kuzvimba kunogona kukonzera kuputika kuve kusanyanya kuitika uye kushoma zvakanyanya.

Iyo zvakare inogona kudzika kana kudzivirira kufambira mberi kwechirwere kunoguma ne psoriatic arthritis (PsA).

Kune avo vanorarama nemhando ipi neipi ye psoriasis, vangangoita makumi matatu muzana vanozoita PsA, iyo inokonzeresa kurwadziwa kwakabatana kwemajoini. PsA inogona kudzikisira hupenyu hwako.

PDE4 inhibitor kurapa vs. mamwe ma psoriasis ekurapa

Apremilast, PDE4 inhibitor, inotorwa nemuromo. Inoitawo munzira yakakosha nekukanganisa mhinduro yekuzvimba iyo inobatsira kune zviratidzo zveplque psoriasis.

Biologic mishonga yakadai saadalimumab (Humira), etanercept (Enbrel), uye infliximab (Remicade) jekiseni mumuviri.

Mimwe mishonga inopindwa muropa inosanganisira:

• Ustekinumab (IL-12/23 inhibitor)
• secukinumab (IL-17A inhibitor)
• ixekizumab (IL-17A inhibitor)
• guselkumab (IL-23 inhibitor)
• risankizumab (IL-23 inhibitor)

Tofacitinib ndiJanus kinase (JAK) inhibitor inobvumidzwa sekurapwa kwemuromo.

Abatacept ndeye T-cell activation inhibitor iyo inopihwa seinopinda (IV) infusion kana jekiseni.

Zvinogona kubatsirwa

Apremilast inokurudzirwa kune vanhu vanorarama zvine mwero kusvika kune yakaoma plaque psoriasis avo zvakare vari kukwikwidza systemic kurapa kana phototherapy.

Mune, chikamu chakakura chevanhu vanotora apremilast vakawana mushe pane ese ari maviri Chiremba Chiremba Ongororo (sPGA) uye Psoriasis Nzvimbo uye Severity Index (PASI) zvichienzaniswa neavo vanotora placebo.

Side migumisiro uye yambiro

Kunyangwe PDE4 inhibitors inoratidza kuvimbisa kukuru, ivo havasi vemunhu wese. Apremilast haina kuongororwa mumadzimai ane pamuviri kana kuyamwisa. Parizvino, inogamuchirwa chete kuvanhu vakuru.

Izvo zvakakoshawo kuyera zvingangoitika njodzi uye mabhenefiti e PDE4 inhibitors.

Apremilast inouya nenjodzi dzinozivikanwa.

Vanhu vanotora apremilast vanogona kusangana nezvakadai se:

• kusvotwa
• manyoka
• chirwere chepamusoro chekufema
• musoro

Vamwe vanhu zvakare vanoona kwakakosha kuonda.

Apremilast inogona zvakare kuwedzera manzwiro ekuora mwoyo uye pfungwa dzekuzviuraya.

Kune vanhu vane nhoroondo yekushungurudzika kana maitiro ekuzviuraya, zvinokurudzirwa kuti vataure nachiremba wavo kuti avabatsire kunyatsoyera zvingabatsire zvemushonga maringe nenjodzi.

Kana iwe ukava nemhedzisiro, chiremba wako anogona kukurudzira kumisa mushonga.

Kutora

Psoriasis inogara - asi inokwanisika - mamiriro. Basa rinoita kuzvimba rinotarisa pakurapa uye kutsvagisa.

Kana chiremba wako akagadza plaque yako psoriasis iri nyoro kana yakachengetedzwa zvakanaka, vanogona kukurudzira nonsteroidal anti-inflammatory drug (NSAIDs). Ivo vanogona zvakare kukurudzira kurapa kwemusoro.

Ivo vangangodaro vanoedza ese maviri aya mazano vasati vafunga nezvekushandisa kwePDE4 inhibitor kana mamwe ma immune modulators.

Vatsvagiri vawana zvimwe nezve maitiro ari mumuviri anokonzera kuzvimba. Ruzivo urwu rwakabatsira mukugadzirwa kwemishonga mitsva inogona kupa zororo kune avo vanorarama ne psoriasis.

PDE4 inhibitors ndiyo yazvino hunyanzvi, asi inouya nenjodzi. Iwe nachiremba wako munofanira kunyatsoongorora zvinhu izvi musati matanga imwe mhando yekurapa.