Peritoneal Cancer: Izvo Zvaunofanira Kuziva

Zvemukati

• Chekutanga vs. chechipiri cheparitoneal cancer
• Primary
• Sekondari
• Zviratidzo zvegomarara reperitoneal
• Matanho ekenza yeparitoneal
• Chirwere chepakutanga cheperitoneal
• Kenza yechipiri peritoneal
• Kenza yePeritoneal inokonzeresa uye njodzi zvinhu
• Kenza yeparitoneal inoonekwa sei
• Maitiro ekuudza musiyano uripo pakati peritoneal cancer uye ovari cancer mune kuongororwa
• Kurapa kenza yeperitoneal
• Kuvhiya
• Chemotherapy
• Targeted kurapwa
• Ndeapi maonero?
• Kupona kwemitengo
• Chirwere chepakutanga cheperitoneal
• Kenza yechipiri peritoneal
• Tsvaga rutsigiro

Kenza yePeritoneal kenza isingawanzoitika inoumbika mune yakatetepa maseru eepithelial ayo anoteya mukati memadziro emudumbu. Iyi lining inonzi iyo peritoneum.

Iyo peritoneum inodzivirira uye inovhara mitezo iri mudumbu rako, kusanganisira iyo:

• ura
• dundira
• rectum
• chibereko

Iyo peritoneum inogadzirawo lubricating fluid inotendera kuti nhengo dzifambe nyore mukati medumbu.

Nekuti zviratidzo zvacho zvinowanzoenda zvisingaonekwe, gomarara reperitoneal rinowanzoonekwa panguva yekupedzisira.

Yese kesi yekenza peritoneal yakasiyana. Kurapa uye maonero anosiyana zvakasiyana. Mishonga mitsva yakagadzirwa mumakumi emakore apfuura yakavandudza huwandu hwekupona.

Chekutanga vs. chechipiri cheparitoneal cancer

Aya mazita epuraimari nesekondari anoreva kuti kenza yakatanga kupi. Mazita haasi iwo muyero wekuti chakakomba sei cancer.

Primary

Kenza yeperitoneal yepakutanga inotanga uye inokura mu peritoneum. Inowanzo bata vakadzi chete uye kashoma kubata varume.

Chirwere chepakutanga cheperitoneal chakabatana zvakanyanya nekenza epithelial ovarian. Vaviri vanobatwa nenzira imwechete uye vane maonero akafanana.

Rudzi rusinganzwisisike rweganda rekutanga rekenza peritoneal is peritoneal malignant mesothelioma.

Sekondari

Kenza yechipiri peritoneal inowanzotanga mune imwe nhengo mudumbu uyezve inopararira (metastasize) kune peritoneum.

Sekenza yekenza peritoneal inogona kutanga mune:

• mazai
• fallopian machubhu
• dundira
• dumbu
• ura hudiki
• colon
• rectum
• appendikisi

Sekenza yekenza peritoneal inogona kubata vese varume nevakadzi. Izvo zvakajairika kupfuura kwepakutanga peritoneal cancer.

Vanachiremba vanofungidzira pakati pegumi neshanu kusvika makumi maviri muzana yevanhu vane gomarara rakakura vanozoita metastases mu peritoneum. Dzakakomberedza gumi kusvika gumi neshanu muzana yevanhu vane gomarara remudumbu vanozoita metastases muperitoneum.

Kana kenza ikasanganisa kubva panzvimbo yayo yekutanga, saiti nyowani ichave nemhando imwechete yekenza maseru senzvimbo yekutanga.

Zviratidzo zvegomarara reperitoneal

Zviratidzo zvegomarara reperitoneal zvinoenderana nerudzi uye nhanho yekenza. Mumatanho ayo ekutanga, panogona kunge pasina zviratidzo. Dzimwe nguva kunyangwe kana gomarara reperitoneal richifambira mberi panogona kunge pasina zviratidzo.

Zviratidzo zvekutanga zvinogona kunge zvisina kujeka uye pamwe zvichikonzerwa nemamwe akawanda mamiriro. Zviratidzo zvecancer peritoneal zvinogona kusanganisira:

• kuzvimba mudumbu kana kurwadziwa
• akawedzera dumbu
• kunzwa kwekumanikidzwa mudumbu kana muchiuno
• kuzara usati wapedza kudya
• kugaya
• kusvotwa kana kurutsa
• ura kana weti kuchinja
• kurasikirwa nenzara
• kuonda kana kuwedzera huremu
• kubuda kwemukadzi
• kurwadziwa shure
• kuneta

Kenza painofambira mberi, mvura yemvura inogona kuunganidzwa mudumbu (ascites), iyo inogona kukonzera:

• kusvotwa kana kurutsa
• mweya wekufema
• kurwadziwa nemudumbu
• kuneta

Zviratidzo zveanonoka-danho peritoneal cancer inogona kusanganisira:

• zadza ura kana kuvhara weti
• kurwadziwa nemudumbu
• kutadza kudya kana kunwa
• kurutsa

Matanho ekenza yeparitoneal

Kana ichinge yatanga kuongororwa, gomarara reperitoneal rakaiswa zvinoenderana nehukuru hwayo, chinzvimbo, uye kwayakapararira kubva. Inopihwa zvakare giredhi, iyo inofungidzira kuti inokurumidza sei kupararira.

Chirwere chepakutanga cheperitoneal

Chirwere chepakutanga cheparitoneal chakaiswa neiyo imwechete sisitimu inoshandiswa kune ovarian cancer nekuti kanzira dzakafanana. Asi gomarara rekutanga reperitoneal rinogara richitorwa sedanho rechitatu kana nhanho 4. Gomarara reOvarian rine maviri ekutanga matanho

Chikamu 3 rakakamurwa kuva mamwe matatu matanho:

• 3A. Gomarara rapararira kuma lymph node kunze kweperitoneum, kana maseru emukenza akapararira kumusoro kweperitoneum, kunze kwechiuno.
• 3B. Gomarara rapararira kune peritoneum kunze kwechiuno. Kenza iri mu peritoneum iri 2 masentimita (cm) kana diki. Inogona kunge yakapararira kune lymph node kunze kweperitoneum.
• 3C. Gomarara rapararira kune peritoneum kunze kwechiuno uye. Kenza iri mu peritoneum yakakura kudarika 2 cm. Inogona kunge yakapararira kune lymph node kunze kweperitoneum kana kumusoro kwechiropa kana spleen.

In nhanho 4, gomarara rapararira kune dzimwe nhengo. Iyi nhanho inowedzera kupatsanurwa:

• 4A. Cancer maseru anowanikwa mune inoyerera inovaka yakatenderedza mapapu.
• 4B. Gomarara rapararira kunhengo uye matishu kunze kwedumbu, senge chiropa, mapapu, kana groin lymph node.

Kenza yechipiri peritoneal

Kenza yechipiri peritoneal yakaiswa zvinoenderana nenzvimbo yekutanga yekenza. Kana gomarara rekutanga rikapararira kune chimwe chikamu chemuviri, senge peritoneum, inowanzo kuverengerwa sedanho rechina rekenza yekutanga.

A yakashuma kuti vangangoita 15 muzana yevanhu vane colorectal cancer uye vangangoita makumi mana muzana yevanhu vane nhanho 2 kusvika ku3 kenza yemudumbu vaive nekubata peritoneal.

Kenza yePeritoneal inokonzeresa uye njodzi zvinhu

Chikonzero chegomarara reperitoneal hachizivikanwe.

Kune yekutanga kenza peritoneal, zvinhu zvine njodzi zvinosanganisira:

• Zera. Sezvaunokura, njodzi yako inowedzera.
• Genetics. Nhoroondo yemhuri yeovarian kana peritoneal cancer inowedzera njodzi yako. Kutakura BRCA1 kana BRCA2 geni mutation kana imwe yemageneti eLynch syndrome inowedzerawo njodzi yako.
• Hormone kurapa. Kutora mahormone kurapwa mushure mekupera zvishoma kunowedzera njodzi yako.
• Kurema uye kukwirira. Kuwedzeredza kana kufutisa kunowedzera njodzi yako. Avo vakareba vari pangozi yakawedzerwa.
• Endometriosis. Endometriosis inowedzera njodzi yako.

Zviitiko zvine chekuita ne zvakaderera njodzi yekenza peritoneal kana ovari inosanganisira:

• kunwa mapiritsi ekudzivirira kubata pamuviri
• kubereka vana
• kuyamwisa
• tubal ligation, fallopian chubhu kubviswa, kana ovary kubviswa

Ziva kuti kubvisa ovary kunoderedza njodzi yekenza yeparitoneal asi hakuibvise zvachose.

Kenza yeparitoneal inoonekwa sei

Kuongororwa kwevese vepuraimari uye vechipiri gomarara reperoneone kwakaoma mumatanho ekutanga. Izvi zvinodaro nekuti zviratidzo zvacho hazvina kujeka uye zvinogona kuve nyore kunzi zvikonzero.

Kazhinji kenza yeparitoneal inongowanikwa chete panguva yekuvhiyiwa kubvisa bundu rinozivikanwa kumwe kunhu mudumbu.

Chiremba wako achakuongorora mumuviri, otora nhoroondo yezvokurapa, uye akubvunze nezve zviratidzo zvako. Ivo vanogona kuraira akateedzana ebvunzo kuti vaone kuongororwa.

Miedzo inoshandiswa kuongorora chirwere cheperitoneal inosanganisira:

• Kufungidzira bvunzo yemudumbu nehudyu. Izvi zvinogona kuratidza ascites kana kukura. Miedzo inosanganisira CT scan, ultrasound, uye MRI. Nekudaro, kenza yeparitoneal iri kushandisa CT neMRI scans.
• Biopsy yenzvimbo inotaridzika kunge isina kujairika mukutarisa, kusanganisira kubviswa kwemvura kubva kuma ascites, kutsvaga masero ane gomarara. Kurukurai zvakanaka nezvakaipa zveizvi nachiremba wako. Maitiro acho zvakare ane njodzi yekudyara madziro emudumbu nemaseru ane cancer.
• Kuongororwa kweropa kutsvaga makemikari anogona kukwidziridzwa mugomarara reperitoneal, senge CA 125, kemikari inogadzirwa nemarara maseru. Mutsva weropa mutsva HE4. Izvo zvishoma pane CA 125 kukwidziridzwa nemamiriro asiri ecancerous.
• Laparoscopy kana laparotomy. Idzi idzi idiki nzira dzinoparadza dzekutarisa zvakananga pa peritoneum. Ivo vanoonekwa se "goridhe standard" mukuongororwa.

Kutsvagurudza munzira dziri nani uye dzekutanga dzekuongororwa kwekenza yeparitoneal iri kuenderera mberi.

A yakaratidza kuvandudzwa kwe "liquid biopsy." Izvi zvinoreva kuongororwa kweropa kunogona kutsvaga mubatanidzwa wemota biomarkers. Izvi zvinogonesa kurapwa kwekutanga kune vamwe vanhu.

Maitiro ekuudza musiyano uripo pakati peritoneal cancer uye ovari cancer mune kuongororwa

Kenza yePeritoneal yakafanana zvikuru nekenza epithelial ovarian cancer. Ose ari maviri anosanganisira mhando imwechete yemasero. Zvirongwa zvakagadzirwa kuvasiyanisa ne.

Inoonekwa seyakanyanya peritoneal cancer kana iyo:

• Mazai anoratidzika seakajairika
• maseru ane gomarara haasi pane ovary pamusoro
• mhando yemota inowanzo serous (kuburitsa fluid)

akataura kuti avhareji zera revanhu vane gomarara rekutanga peritoneal raive rakakura pane avo vane epithelial ovarian cancer.

Kurapa kenza yeperitoneal

Iwe unogona kunge uine timu yekurapa inosanganisira:

• chiremba anovhiya
• oncologist
• chiremba weradhiyo
• chiremba wezvirwere
• gastroenterologist
• nyanzvi yekurwadziwa
• manesi akakosha
• nyanzvi dzekuchengetedza

Kurapa kwegomarara reperitoneal kwakafanana neiya yekenza yeovarian. Kune ese epamberi uye echipiri kenza yeperitoneal, kurapwa kwega kunoenderana nenzvimbo uye saizi yebundu uye hutano hwako.

Kurapa kwekenza yechipiri peritoneal kunoenderana nemamiriro ekenza yepakutanga uye mhinduro yako pakurapwa kwayo.

Kuvhiya

Kuvhiya kunowanzo kuve danho rekutanga. Chiremba anovhiya achabvisa yakawanda yekenza sezvinobvira. Ivo vanogona zvakare kubvisa:

• dumbu rako (hysterectomy)
• mazai ako uye fallopian machubhu (oophorectomy)
• hutete hwemafuta ane mafuta padhuze nemazai (omentum)

Chiremba wako anovhiya achabvisa chero zvinyama zvisina kujairika mudumbu kuti uenderere mberi nekuyedzwa.

Kufambira mberi mukunyatsoita kwehunyanzvi hwekuvhiya, kunozivikanwa sekuvhiya kwecytoreductive (CRS), kwagonesa vanovhiya kubvisa zvimwe zvegomarara. Izvi zvakavandudza maonero evanhu vane gomarara reperitoneal.

Chemotherapy

Chiremba wako anogona kushandisa chemotherapy asati avhiyiwa kudzikisa bundu iri mukugadzirira kuvhiya. Vanogona zvakare kuishandisa mushure mekuvhiyiwa kuuraya chero maseru ane cancer.

Nzira nyowani yekuendesa chemotherapy mushure mekuvhiyiwa yakawedzera kushanda kwayo muzviitiko zvakawanda.

Iyo hunyanzvi inoshandisa kupisa kwakabatana pamwe nekemotherapy inounzwa yakanangana kune iyo peritoneal kenza saiti. Inozivikanwa sehyperthermic intraperitoneal chemotherapy (HIPEC). Iyi inguva-imwe yekurapa yakapihwa chaipo mushure mekuvhiyiwa.

Iko kusanganiswa kweCRS neHIPEC "kwakachinja" kurapwa kwekenza peritoneal, sekureva kwevaongorori vazhinji. Asi haina kugamuchirwa zvizere seyakajairika kurapwa. Izvi zvinodaro nekuti hapana maratidziro emurwere miedzo nemapoka ekudzora.

Kutsvagisa kuri kuenderera. HIPEC haina kukurudzirwa kana paine metastases kunze kwedumbu uye mune mamwe mamiriro.

Yese chemotherapy ine mhedzisiro. Kurukurai kuti izvi zvingave zvipi uye kuti ungazvibata sei neboka rako rekurapa.

Targeted kurapwa

Mune zvimwe zviitiko, yakanangwa yekurapa mushonga inogona kushandiswa. Iyi mishonga yakanangana nekumisa cancer maseru pasina kukuvadza zvakajairika maseru. Mishonga inotarisirwa inosanganisira zvinotevera:

• Monoclonal antibodies tarisa zvinhu pane maseru anokurudzira cancer cancer kukura. Izvi zvinogona kusanganiswa nekemotherapy mushonga.
• PARP (poly-ADP ribose polymerase) inhibitors bvisa DNA kugadzirisa.
• Angiogenesis inhibitors kudzivirira ropa reropa kukura mumamota.

Hormonal therapy, radiation radiation, uye immunotherapy inogona zvakare kushandiswa mune dzimwe nguva yekenza yekutanga peritoneal.

Ndeapi maonero?

Maonero evanhu vane gomarara repuraimari kana yechipiri peritoneal yakagadziriswa zvakanyanya mumakumi emakore apfuura nekuda kwekufambira mberi kwekurapa, asi ichiri murombo. Izvi zvinonyanya nekuti kenza yeperitoneal kazhinji haina kuongororwa kusvikira yave padanho repamberi. Zvakare, gomarara rinogona kudzoka mushure mekurapwa.

Zviratidzo zvakaoma kujekesa, asi kana uine zvimwe zvezviratidzo zvinoenderera, tarisa nachiremba wako. Pakutanga kuongororwa kunotungamira kumhedzisiro iri nani.

Kupona kwemitengo

Chirwere chepakutanga cheperitoneal

Kubva muna2019, makore mashanu ekupona kwevakadzi vane ese marudzi eovarian, fallopian tube, uye peritoneal cancer ndeye 47 muzana. Iyi nhamba yakakwira kune vakadzi vari pasi pe65 (60 muzana) uye yakaderera kune vakadzi vanopfuura makumi matanhatu nemashanu (29 muzana).

Kupona kwehuwandu hwekenza yekutanga peritoneal kenza kunouya kubva kune zvidiki zvidzidzo.

Semuenzaniso, mumwe wevakadzi makumi maviri nevapfumbamwe vane gomarara rekutanga peritoneal vakashuma avhareji yekupona nguva yemwedzi makumi mana nemasere mushure mekurapwa.

Izvi zviri nani zvakanyanya kupfuura makore mashanu ekupona akataurwa muongororo ya1990 yaive pakati.

Kenza yechipiri peritoneal

Kupona kwehuwandu hwekenza yechipiri peritoneal zvakare kunoenderana padanho repakutanga kenza saiti uye mhando yekurapa. Chiverengero chidiki cheongororo chinoratidza kuti kurapa kwakabatana kweCRS neHIPEC kunovandudza kupona kwehuwandu.

Semuenzaniso, chidzidzo chakataurwa muna2013 chakatarisa vanhu makumi masere nevatanhatu vane kenza yakajeka iyo yakanga yapararira kune peritoneum. Iyo yaifananidza avo vaive systemic chemotherapy kune avo vaive neCRS neHIPEC.

Kupona kwechemotherapy boka kwaive mwedzi makumi maviri nemaviri nemakumi matatu nematanhatu zvichienzaniswa nemwedzi 62.7 yeboka rakarapwa neCRS neHIPEC.

Tsvaga rutsigiro

Ungangoda kutaura nevamwe vanhu vachienda nekurapwa kana nenhengo dzemhuri.

Mutsara weAmerican Cancer Society unowanikwa 24/7 pazuva pa800-227-2345. Vanogona kukubatsira iwe kuti uwane online kana boka remunharaunda kuti utsigire.

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