Rituxan yeMS

Zvemukati

• Nezve off-label kushandisa zvinodhaka
• Rituxan yakachengeteka uye inoshanda pakurapa MS?
• Inoshanda here?
• Kwakachengeteka here?
• Ndeupi musiyano uripo pakati peRituxan naOcrevus?
• Kutora

Mhedziso

Rituxan (generic zita rituximab) mushonga unonyorwa unonongedza puroteni inonzi CD20 mune immune system B masero. Yakagamuchirwa neU.S. Food and Drug Administration (FDA) yekurapa zvirwere zvakaita seNon-Hodgkin's lymphoma uye rheumatoid arthritis (RA).

Vanachiremba dzimwe nguva vanopa Rituxan yekurapa multiple sclerosis (MS), kunyangwe iyo FDA isina kuibvumidza iko kushandiswa. Izvi zvinonzi "off-label" kushandisa zvinodhaka.

Nezve off-label kushandisa zvinodhaka

Kushandisa-kurebesa kushandisa zvinodhaka zvinoreva kuti mushonga unobvumidzwa neDFA nechinangwa chimwe unoshandiswa nechinangwa chakasiyana chisina kubvumidzwa.

Nekudaro, chiremba achiri kugona kushandisa mushonga wechinangwa icho. Izvi zvinodaro nekuti iyo FDA inodzora kuyedzwa uye kubvumidzwa kwemishonga, asi kwete mashandisiro anoita vanachiremba mishonga yekurapa varwere vavo. Saka chiremba wako anokwanisa kukunyorera mushonga asi ivo vanofunga zvakanakira iwe. Dzidza zvakawanda nezve off-label tsamba yekushandisa zvinodhaka.

Kana chiremba wako achikunyorera mushonga wekuti ushandise-zvisiri izvo, unofanirwa kunzwa wakasununguka kubvunza chero mibvunzo yaungave unayo. Iwe une kodzero yekuve nechekuita mune chero sarudzo pamusoro pekuchengetwa kwako.

Mienzaniso yemibvunzo iwe yaunogona kubvunza inosanganisira:

• Nei wakaraira kushandiswa-kwemavara kushandiswa kwechirwere ichi?
• Pane here mimwe mishonga inogamuchirwa iripo inogona kuita zvakafanana?
• Inishuwarenzi yangu yehutano ichavhara here izvi-zvisiri zvekushandisa zvinodhaka?
• Unoziva here mhedzisiro yandinogona kuve nayo kubva kumushonga uyu?

Rituxan yakachengeteka uye inoshanda pakurapa MS?

Iko hakuna kubvumirana pamusoro pekuti Rituxan yakachengeteka uye inoshanda sei yekurapa MS, asi zvidzidzo zvinoratidza kuti inoratidza chivimbiso.

Inoshanda here?

Kunyangwe pakange pasina kukwana kwakaringana kwechokwadi-kwepasirese zvidzidzo zvekunyatso kutonga Rituxan semushonga unoshanda weMS, zviratidzo zvakanaka zvinoratidza kuti zvinogona kunge zviri.

Chidzidzo cheSweden MS registry yakafananidza Rituxan neyechinyakare yekutanga chirwere chinoshandura sarudzo dzekurapa senge

• Tecfidera (dimethyl fumarate)
• Gilenya (fingolimod)
• Tysabri (natalizumab)

Panyaya yekumiswa kwezvinodhaka uye kushanda kwehunyanzvi mukudzokororazve-kuregedza akawanda sclerosis (RRMS), Rituxan kwete chete yaive inotungamira sarudzo yekurapa kwekutanga, asi zvakare yakaratidza mhedzisiro yakanaka.

Kwakachengeteka here?

Rituxan inoshanda seB-cell inopedza mumiririri. Zvinoenderana, kupera kwenguva refu kwemasero eB peripheral kuburikidza neRituxan inoita kunge yakachengeteka, asi kumwe kudzidza kunodiwa.

Zvikanganiso zveRituxan zvinogona kusanganisira:

• infusion maitiro akadai sekuputika, kuchenesa, uye kuzvimba
• matambudziko emwoyo akadai sekusagadzikana kwemoyo zvisina kujairika
• matambudziko eitsvo
• maronda anobuda ropa
• kurwadziwa nemudumbu
• kupindwa nechando
• chills
• zvirwere
• muviri kurwadza
• kusvotwa
• mapundu
• kuneta
• masero machena eropa
• kunetseka kurara
• rurimi rwakazvimba

Iwo ekuchengetedza profiles emamwe marapirwo akadai seGilenya neTysabri kune vanhu vane MS vane zvinyorwa zvakawandisa kupfuura Rituxan.

Ndeupi musiyano uripo pakati peRituxan naOcrevus?

Ocrevus (ocrelizumab) mushonga unogamuchirwa neDFA unoshandiswa pakurapa RRMS uye yekutanga inofambira mberi yakawanda sclerosis (PPMS).

Vamwe vanhu vanotenda kuti Ocrevus ingori rebranded vhezheni Rituxan. Ivo vaviri vanoshanda nekunongedza B maseru nemaCD20 mamorekuru pamusoro pawo.

Genentech - anovandudza zvese zvinodhaka - anoti pane mamorekuru misiyano uye kuti mishonga yega yega inobatana nema immune system zvakasiyana.

Mumwe musiyano mukuru ndewekuti marongero ehutano mazhinji ehutano anovhara Ocrevus yeMS kurapwa kupfuura Rituxan.

Kutora

Kana iwe - kana mumwe munhu ari padyo newe - uine MS uye iwe uchinzwa kuti Rituxan inogona kunge iri imwe nzira yekurapa, kurukura nezveiyi sarudzo nachiremba wako. Chiremba wako anogona kupa nzwisiso yemhando dzakasiyana dzekurapa uye nemabatiro avanogona kuita kune ako chaiwo mamiriro.