Chii Chinoita Kuti Mantle Cell Lymphoma Akasiyana Kubva Kune Dzimwe Lymphomas?

Zvemukati

• MCL iB-cell isiri-Hodgkin's lymphoma
• MCL inowanzo bata varume vakuru
• MCL haina kujairika zvachose
• Inopararira kubva munzvimbo yemachira
• Iyo inosanganisirwa neakasarudzika maseru ekuchinja
• Ine hukasha uye yakaoma kurapa
• Inogona kurapwa nemishonga yakanangwa
• Kutora

Lymphoma kenza yeropa inokura mune ma lymphocyte, rudzi rweye chena reropa reropa. MaLymphocyte anoita basa rakakosha muma immune system. Kana dzikaita gomarara, dzinowanda zvisingaite uye dzinokura kuita mamota.

Kune akawanda marudzi e lymphoma. Iyo yekurapa sarudzo uye maonero anosiyana kubva kune imwe mhando kuenda kune imwe. Tora kanguva kuti udzidze kuti mantle cell lymphoma (MCL) inofananidzwa sei nemamwe marudzi echirwere ichi.

MCL iB-cell isiri-Hodgkin's lymphoma

Kune maviri akakosha marudzi e lymphoma: Hodgkin's lymphoma uye isiri Hodgkin's lymphoma. Kune anopfuura makumi matanhatu madiki emhando yeasina-Hodgkin's lymphoma. MCL ndomumwe wavo.

Kune maviri akakosha marudzi ema lymphocyte: T lymphocyte (T maseru) uye B lymphocyte (B maseru). MCL inobata masero eB.

MCL inowanzo bata varume vakuru

Sekureva kweAmerican Cancer Society, Hodgkin's lymphoma kazhinji inobata vechidiki, kunyanya vanhu vane makore ekuma20. Nokuenzanisa, MCL uye mamwe marudzi asiri eHodgkin's lymphoma anowanzoitika kune vakura vakuru. Lymphoma Research Foundation inoshuma kuti vanhu vazhinji vane MCL varume vanopfuura makore makumi matanhatu.

Pakazara, lymphoma ndeimwe yemhando dzakajairika dzegomarara kubata vana nevechiri kuyaruka. Asi kusiyana nemamwe marudzi e lymphoma, MCL isingawanzo kuitika muvechidiki.

MCL haina kujairika zvachose

MCL yakanyanya kushoma pane mamwe marudzi e lymphoma. Iyo inoverengera angangoita mashanu muzana emakesi ese emakomoma, maererano neAmerican Cancer Society. Izvi zvinoreva kuti MCL inomiririra inenge 1 mune makumi maviri ema lymphomas.

Saizvozvowo, mhando yakajairika yeasina-Hodgkin's lymphoma inoparadzira yakakura B-cell lymphoma, iyo inoverengera ingangoita 1 mu3 lymphomas.

Nemhaka yekuti inenge isingawanzoitiki, vanachiremba vazhinji vanogona kunge vasina kujairana neazvino matsva uye nzira dzekurapa dzeMCL. Kana zvichikwanisika, zviri nani kushanyira oncologist iyo inonyanya kugadzirisa lymphoma kana MCL.

Inopararira kubva munzvimbo yemachira

MCL inowana zita rayo kubva pachokwadi chekuti inoumba munzvimbo yekumusoro ye lymph node. Iyo mantle zone iringi yema lymphocyte ayo anotenderedza pakati penzvimbo yema lymph node.

Panguva iyo inoonekwa, MCL yakagara ichipararira kune mamwe ma "lymph node", pamwe nemamwe matukisi nenhengo. Semuenzaniso, inogona kupararira kumabhonzo ako emapfupa, spleen, uye ura. Muzviitiko zvisingawanzoitika, zvinogona kukanganisa huropi hwako uye musana.

Iyo inosanganisirwa neakasarudzika maseru ekuchinja

Kuzvimba lymph node ndicho chiratidzo chinowanzozivikanwa cheMCL uye mamwe marudzi e lymphoma. Kana chiremba wako achifungidzira kuti une lymphoma, ivo vachatora sosi sampu kubva kune yakazvimba lymph node kana zvimwe zvikamu zvemuviri wako kuti uongorore.

Pasi pe microscope, masero eMCL anotaridzika akafanana nemamwe marudzi e lymphoma. Asi muzviitiko zvakawanda, masero ane mavara emagetsi anogona kubatsira chiremba wako kudzidza kuti ndeapi rudzi rwe lymphoma iwo. Kuti uwane kuongororwa, chiremba wako acharaira bvunzo kuti atarise chaiwo mamaki uye mapuroteni.

Chiremba wako anogona zvakare kuraira kumwe bvunzo, senge CT scan, kuti udzidze kana gomarara rapararira. Ivo vanogona zvakare kuraira biopsy yemapfupa ako mongo, ura, kana mamwe matukisi.

Ine hukasha uye yakaoma kurapa

Mimwe mhando yeasina-Hodgkin's lymphoma yakaderera-giredhi kana kusagadzikana. Izvi zvinoreva kuti vanowanzo kukura zvishoma, asi kazhinji havarapike. Kurapa kunogona kubatsira kudzikisa kenza, asi yakaderera-giredhi lymphoma kazhinji inodzokazve, kana kudzoka.

Dzimwe mhando dzisiri-Hodgkin's lymphoma dzakakwira-giredhi kana hasha. Vanowanzokura nekukurumidza, asi vanowanzo kurapwa. Kana kurapwa kwekutanga kwabudirira, yepamusoro-grade lymphoma haiwanzo kudzokazve.

MCL haina kujairika pakuti inoratidza maficha eepamusoro-giredhi uye epasi-giredhi lymphomas. Kufanana nemamwe eepamusoro-grade lymphomas, inowanzo kukura nekukurumidza. Asi senge yakaderera-giredhi lymphomas, kazhinji haina kurapwa. Vanhu vazhinji vane MCL vanoenda mukuregererwa mushure mekurapwa kwavo kwekutanga, asi gomarara rinowanzo dzoka mukati memakore mashoma.

Inogona kurapwa nemishonga yakanangwa

Kufanana nemamwe marudzi e lymphoma, MCL inogona kurapwa neimwe kana imwe yedzinotevera nzira:

• vakamirira vakamirira
• chemotherapy zvinodhaka
• monoclonal antibodies
• mubatanidzwa chemotherapy uye antibody kurapwa inonzi chemoimmunotherapy
• radiation kurapwa
• stem sero kuisazve

Chikafu neDrug Administration (FDA) yakabvumidzawo mishonga mina iyo inonongedza zvakanyanya MCL:

• bortezomib (Velcade)
• lenalidomide (Revlimid)
• ibrutinib (Imbruvica)
• acalabrutinib (Calquence)

Yese mishonga iyi yakagamuchirwa kuti ishandiswe panguva yekudzokazve, mushure mekunge kumwe kurapwa kwamboedzwa. Bortezomib yakagamuchirwawo senzira yekutanga kurapwa, iyo inogona kushandiswa pamberi pedzimwe nzira. Akawanda emakiriniki ekuedzwa ari kuenderera mberi kuti ashandise kushandiswa kwelenalidomide, ibrutinib, uye acalabrutinib sekutanga-mutsara marapirwo, futi.

Kuti udzidze zvakawanda nezvesarudzo dzako dzekurapa, taura nachiremba wako. Zano ravo rekurapa rinokurudzirwa rinoenderana nezera rako uye hutano hwakazara, uyezve kuti gomarara riri kukura mumuviri wako kupi uye sei.

Kutora

MCL haina kujairika uye inonetsa kurapa. Asi mumakore achangopfuura, marapirwo matsva akagadzirwa uye akabvumidzwa kunongedza rudzi urwu rwegomarara. Aya marapirwo matsva akawedzera zvakanyanya hupenyu hwevanhu vane MCL.

Kana zvichikwanisika, zviri nani kushanyira nyanzvi yekenza ine ruzivo rwekurapa lymphoma, kusanganisira MCL. Iyi nyanzvi inogona kukubatsira kuti unzwisise uye kuyera zvaunogona kurapwa.