Prothrombin kushomeka

Prothrombin kushomeka chirwere chinokonzerwa nekushaikwa kweprotein muropa inonzi prothrombin. Inotungamira kumatambudziko nekugwamba kweropa (coagulation). Prothrombin inozivikanwawo sechinhu chechipiri (chechipiri).

Paunobuda ropa, akateedzana maitiro anoitika mumuviri ayo anobatsira kuwanda kweropa fomu. Maitiro aya anonzi coagulation cascade. Inosanganisira mapuroteni akasarudzika anonzi coagulation, kana kugwamba, zvinhu. Unogona kuve nemukana wakakwirira wekubuda ropa zvakawandisa kana chimwe kana zvimwe zvezvinhu izvi zvisipo kana zvisiri kushanda sezvavanofanira.

Prothrombin, kana factor II, ndechimwe chakadaro coagulation factor. Prothrombin kushomeka kunomhanya mumhuri (nhaka) uye hakuwanzoitika. Vabereki vaviri vanofanirwa kuve nejenasi yekuendesa chirwere kuvana vavo. Nhoroondo yemhuri yechirwere chekubuda ropa inogona kuita njodzi.

Prothrombin kushomeka kunogona zvakare kuve nekuda kweimwe mamiriro kana kushandiswa kwemimwe mishonga. Izvi zvinonzi zvakawanikwa prothrombin kushomeka. Inogona kukonzerwa ne:

• Kushaya vhitamini K (vamwe vacheche vanozvarwa vaine vhitamini K kushomeka)
• Chirwere chakakomba chechiropa
• Kushandiswa kwemishonga inodzivirira kugwamba (anticoagulants senge warfarin)

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kubuda ropa zvisina kujairika mushure mekusununguka
• Kubuda kumwedzi kwakanyanya kubuda ropa
• Kubuda ropa mushure mekuvhiyiwa
• Kubuda ropa mushure mekukuvara
• Kutuka zviri nyore
• Mhino dzemhino dzisingamire nyore
• Tambo yembilical ichibuda ropa mushure mekuzvarwa

Miedzo inogona kuitwa inosanganisira:

• Chinhu chechipiri II kuyedza
• Yakasarudzika thromboplastin nguva
• Prothrombin nguva (PT)
• Kusanganisa kudzidza (yakakosha PTT bvunzo yekusimbisa prothrombin kushomeka)

Kubuda ropa kunogona kudzorwa nekutora intravenous (IV) infusions yeplasma kana concentrate yezvinhu zvinogwamba. Kana iwe uchinge usisina vhitamini K, unogona kutora vhitamini iyi nemuromo, kuburikidza nemajekiseni pasi peganda, kana kuburikidza nemutsinga (mukati).

Kana iwe uine chirwere ichi chekubuda ropa, ita shuwa ku:

• Udza vanokupa hutano usati waita chero maitiro, kusanganisira kuvhiya uye basa remazino.
• Udza nhengo dzemhuri yako nekuti vanogona kunge vaine chirwere chakafanana asi havasati vazviziva.

Izvi zviwanikwa zvinokwanisa kupa rumwe ruzivo nezve kushomeka kweFactor VII:

• National Hemophilia Foundation: Zvimwe Kusakwana Kwezvinhu - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• NIH Genetic uye Rare Zvirwere Ruzivo Ruzivo - rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

Mhedzisiro yacho yakanaka nekurapwa kwakakodzera.

Iyo yekugara nhaka prothrombin kushomeka kwehupenyu hwese mamiriro.

Maonero ekuwana kushomeka kweprothrombin zvinoenderana nechikonzero. Kana iyo ichikonzerwa nechirwere chechiropa, mhedzisiro inoenderana nekuti chirwere chechiropa chako chinogona kurapwa sei. Kutora zvinowedzera vhitamini K kuchabata kushomeka kwevhitamini K.

Kubuda ropa kwakanyanya munhengo kunogona kuitika.

Wana kurapwa kwechimbichimbi ipapo kana usina kutsanangudza kana kurasikirwa kwenguva refu kweropa, kana kana iwe usingakwanise kudzora kubuda kweropa.

Iko hakuna kuzivikanwa kudzivirira kwekugara nhaka prothrombin kushomeka. Kana kushomeka kwevhitamini K chiri chikonzero, kushandisa vhitamini K kunogona kubatsira.

Hypoprothrombinemia; Chinhu chechipiri kushomeka; Dysprothrombinemia

• Ropa kugadzirwa
• Ropa rinovhara

Gailani D, Wheeler AP, Neff AT. Kazhinji coagulation factor kushaikwa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 137.

Horo JE. Hemostasis uye kuwanda kweropa. Mune: Horo JE, ed. Guyton uye Horo Chinyorwa cheMedhi Physiology. 13 ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 37.

Ragni MV. Hemorrhagic kusagadzikana: coagulation factor kushomeka. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 174.