Inogona here Ibuprofen kuwedzera zviratidzo zve COVID-19?
Zvemukati
Iko kushandiswa kweIbuprofen uye mamwe asiri-steroidal anti-anogumbura madhiragi (NSAIDs) panguva yekutapukirwa neSARS-CoV-2 inoonekwa seyakachengeteka, nekuti zvaisaita kusimbisa hukama pakati pekushandisa kwechirwere ichi uye kuwedzera kwezviratidzo zvekufema zve denda re COVID. 19.
Uye zvakare, chidzidzo chakaitwa muIsrael [1] kuongororwa varwere vakashandisa ibuprofen kwevhiki pasati paonekwa COVID-19 uye panguva yekurapwa kwekuzorora kwechiratidzo pamwe neparacetamol uye vakaona kuti kushandiswa kweibuprofen hakuna hukama nekuwedzera kwevarwere kiriniki mamiriro.
Nekudaro, hapana humbowo hwekuti kushandiswa kweibuprofen kunogona kuwedzera kuora uye kufa kweCOVID-19 uye, nekudaro, kushandiswa kwemushonga uyu kunoratidzwa nevakuru vehutano, uye kunofanirwa kushandiswa pasi pekurudziro yekurapa.
Nei ibuprofen ichiwedzera hutachiona?
Chidzidzo chakaburitswa mumagazini Lancet Kufema Mushonga [2] inotaura kuti ibuprofen inogona kuwedzera zviratidzo kune vanhu vane hutachiona hwehutachiona hwehutachiona, sezvo mushonga uyu uchikwanisa kuwedzera kutaura kweACE, inova inogamuchirwa inowanikwa mumasero evanhu uye inosungawo kune coronavirus nyowani. Chirevo ichi chakavakirwa pachokwadi chekuti vane chirwere cheshuga uye vane hutachiona hwakanyanya vaive nenhamba yepamusoro yevanoratidza maCEC, vakashandisa ibuprofen nedzimwe NSAID uye vakagadzira zvakanyanya COVID-19.
Chimwe chidzidzo chakaitwa nemakonzo ane chirwere cheshuga[3], yakasimudzira kushandiswa kweibuprofen kwemavhiki masere muzvidimbu zvakaderera pane zvakakurudzirwa, zvichikonzera kuwedzera kwekuratidzwa kweiyo enzyme inoshandura angiotensin 2 (ACE2) munyama yemwoyo.
Enzyme imwecheteyo, ACE2, inoita kunge imwe yeanopinda mavhairasi emhuri yekoronavirus mumasero, uye nekuda kwechikonzero ichi, mamwe masayendisiti anofungidzira kuti kana paine kuwedzera kwekutaura kweiyo enzyme muvanhu, kunyanya mapapu, zvinokwanisika kuti hutachiona hunogona kuwedzera nekukurumidza, zvichikonzera zviratidzo zvakanyanya.
Chii chinozivikanwa
Kunyangwe hazvo zvidzidzo zvakaburitswa nezvehukama husina kunaka pakati pebuprofen neCOVID-19, iyo World Health Organisation nevamwe vakuru vehutano vakaratidza kuti hapana humbowo hwesainzi hwekuti kushandiswa kwebuprofen kwaisazove kwakachengeteka, nekuti mhedzisiro yakapihwa yaive yakavakirwa pane zvekufungidzira uye kwete zvidzidzo zvevanhu zvakatomboitwa. Mukuwedzera, zvimwe zvidzidzo zvakaratidza izvozvo [4]:
- Iko hakuna humbowo hwakananga hwekuti ibuprofen inogona kudyidzana neSARS-CoV-2;
- Iko hakuna humbowo hwekuti ibuprofen ine basa rekuwedzera kutaura kweiyo angiotensin-inoshandura enzyme;
- Zvimwe zvemu vitro zvidzidzo zvakaratidza kuti ibuprofen inogona "kutyora" iyo ACE receptor, ichiita kuti zviomere kusangana kwesero membrane-hutachiona uye kudzikisira njodzi yehutachiona hunopinda muchitokisi nenzira iyi;
- Iko hakuna humbowo hwekuti kushandiswa kweibuprofen kunogona kuwedzera kana kuwedzera njodzi yehutachiona.
Zvisinei, zvimwe zvidzidzo zvichiri kudiwa kuti zvionekwe kusavapo kwehukama pakati peSARS-CoV-2 uye kushandiswa kweibuprofen kana mamwe maNSAID uye kuona kushandiswa kwakachengeteka kwemishonga iyi.
Zvaunofanira kuita kana iwe uine zviratidzo
Panyaya yezviratidzo zvinyoro zve COVID-19, senge fivha, kukosora kwakanyanya uye musoro, semuenzaniso, pamusoro pekuzviparadzanisa, zvinokurudzirwa kubvunza chiremba kuitira kuti nhungamiro ipiwe sekumushonga unoshandiswa kugadzirisa chiratidzo, kushandiswa kweparacetamol kana ibuprofen kunogona kuratidzwa, kunofanirwa kushandiswa zvinoenderana nezano rekurapa.
Nekudaro, kana zviratidzo zvikanyanya, uye pangave nekuomerwa mukufema uye kurwadziwa pachipfuva, chinhu chakanakisa ndechekuti munhu wacho aende kuchipatara kuitira kuti kuongororwa kwe COVID-19 kusimbiswe uye kurapwa kwakanyanya kunogona kutanga. pamwe nekurapwa chinangwa chekudzivirira mamwe matambudziko nekusimudzira hupenyu hwemunhu. Hwisisa kuti marapirwo anoitwa sei COVID-19.
Tinokurudzira
Necrobiosis lipoidica chirwere cheshuga
